Efficacy of prophylactic hemoclip placement for preventing delayed post-polypectomy bleeding in nonpedunculated colorectal lesions: updated meta-analysis and trial sequential analysis of randomized controlled trials.

Yaping Wei, Haojie He, Hawa Suleiman Mabenga, Brenda John Ngowi, Zheng Jin

Abstract readReview

In one paragraph

Review in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yaping Wei *Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, #261 Huansha Road, Hangzhou, 310006, Zhejiang Province, China.

Haojie He *Zhejiang Chinese Medical University, Hangzhou, China.

Hawa Suleiman MabengaZhejiang Chinese Medical University, Hangzhou, China.

Brenda John NgowiZhejiang Chinese Medical University, Hangzhou, China.

Zheng JinAffiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, #261 Huansha Road, Hangzhou, 310006, Zhejiang Province, China. kingz1025@163.com.ORCID http://orcid.org/0000-0003-3940-2982

Funding

Hangzhou Municipal Health Science and Technology Program A20252150Medical Science and Technology Project of Zhejiang Province 2024KY169Zhejiang Province Traditional Chinese Medicine Science and Technology Program 2024ZL720

6 · The paper itself

Abstract

BACKGROUND AND

aimsEvidence regarding prophylactic hemoclip (HC) for preventing delayed post-polypectomy bleeding (DPPB) remains inconsistent. This meta-analysis with trial sequential analysis (TSA) aimed to evaluate HC after thermal resection of nonpedunculated colorectal polyps.

methodsMEDLINE, Embase, and the Cochrane Library were searched through 28 July 2026 for randomized controlled trials (RCTs) comparing HC with non-HC after thermal resection of nonpedunculated colorectal polyps ≥ 5 mm. The primary outcome was DPPB. Secondary outcomes included DPPB for proximal large (≥ 20 mm) nonpedunculated colorectal polyps (LNPCPs), other adverse events, and procedure time. Random-effects models, subgroup analyses, GRADE, and TSA were applied.

resultsTen RCTs involving 4,588 patients were included. HC reduced DPPB overall (3.4 vs. 6.5%; RR 0.51; 95% CI 0.34-0.76; P < 0.001; I

conclusionsProphylactic HC closure reduces DPPB after thermal resection of nonpedunculated colorectal polyps ≥ 5 mm, including proximal LNPCPs. Clinical use should consider lesion characteristics, procedural factors, and individualized bleeding risk.

Indexed as

Colorectal polypsDelayed post-polypectomy bleedingEndoscopic mucosal resectionNonpedunculatedProphylactic clippingTrial sequential analysis

Identifiers

PMID42875632

DOI10.1007/s00464-025-12199-x

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.