ArticleInsights into imaging2026
Estimation of glomerular filtration rate by standard renal CT imaging.
Article in Insights into imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
objectivesTo develop and evaluate a method to predict glomerular filtration rate (GFR) from clinical renal CT. MATERIALS AND
methodsMedical records of adult living kidney donors operated between 2013 and 2022 and patients considered for neoadjuvant cisplatin prior to cystectomy between 2019 and 2024 were retrospectively reviewed. Inclusion criteria were (1) renal CT obtained at 100 or 120 kVp before and 5-15 min after contrast administration, and (2) iohexol clearance test within 2 months of imaging. The iohexol clearance test was performed on the same day as the cystatin C and creatinine measurements. Estimated GFR values included cystatin C-based eGFR (eGFR
resultsIn total, 139 patients were included in the analysis (mean age 52 ± 13 years; 60% women). Multivariate linear regression analysis combining the segmentation-derived variable with body surface area and age gave an adjusted R-square of 0.77 to mGFR
conclusionRenal function can be estimated with high precision from clinical renal CT. KEY POINTS: Question Accurate GFR assessment is critical, but current methods are either labor-intensive or imprecise. Can renal CT imaging provide a reliable alternative? Findings CT-derived eGFR showed the strongest correlation with iohexol clearance (R² = 0.77), with lower error compared to creatinine- and cystatin C-based estimates. Critical relevance statement Routine CT imaging can provide precise estimates of kidney function, supporting donor evaluations, chemotherapy dosing, and critical care decisions when accurate renal function is essential.
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