Evidence map›Paper›PMID 42875547›Full record

ArticleNature immunology2026

Evidence for maternal autoantibodies in the pathogenesis of preterm birth.

Elze Rackaityte, Beltran Borges, Hannah M Kortbawi, Haleigh S Miller, Shirley J Shao, Kelsey C Zorn, Colette Caspar, Rebecca Wong, Frank McCarthy, Joseph S Creery and 40 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors.

Elze RackaityteDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3889-8082
Beltran BorgesDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Hannah M KortbawiDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Haleigh S MillerDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Shirley J ShaoDepartment of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Kelsey C ZornDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1227-2137
Colette CasparDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0009-0008-6803-1600
Rebecca WongDepartment of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Frank McCarthyChan Zuckerberg Biohub San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-7933-6847
Joseph S CreeryChan Zuckerberg Biohub San Francisco, San Francisco, CA, USA.
Margareta MayerThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3423-9127
Madhura RaghavanDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Elaine KouameThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA, USA.
Robert R PuccinelliUC Berkeley - UCSF Graduate Program in Bioengineering, University of California San Francisco, San Francisco, CA, USA.
Amy L KistlerChan Zuckerberg Biohub San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1112-719X
David J L YuDiabetes Center, School of Medicine, University of California San Francisco, San Francisco, CA, USA.
Sammer Roach GanemDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Alexandra DeRisiDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Quinn KawajaDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Chung-Yu WangChan Zuckerberg Biohub San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2236-0264
Aditi SaxenaChan Zuckerberg Biohub San Francisco, San Francisco, CA, USA.
Scott OltmanDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6560-3334
Andrew F KungDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Sabrina A MannDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Anthea MitchellDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
David HuangDepartment of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Gabrielle RizzutoImmuno-Oncology Program and Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-3052-0253
Rebecca J BaerDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8485-1977
Caleigh Mandel-BrehmDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
Kelli K RyckmanDepartment of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA.ORCID http://orcid.org/0000-0002-9496-4147
Stephanie L GawDepartment of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0891-6964
Sara L HillmanMaternal and Fetal Medicine Department, Institute for Women's Health, University College London, London, UK.
Laura L Jelliffe-PawlowskiDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Joanna HalkiasThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0721-8961
Nasim C SobhaniDepartment of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Mark S AndersonDiabetes Center, School of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3093-4758
Francsesca TrespidiHost-Pathogen Interaction Group and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.ORCID http://orcid.org/0009-0007-7206-6796
Claudia AlpiniLaboratory of Biochemical-Clinical Analyses, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Tiziana BosoniLaboratory of Biochemical-Clinical Analyses, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Riccardo AlbertiniLaboratory of Biochemical-Clinical Analyses, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Camilla BellingeriDepartment of Obstetrics and Gynecology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.ORCID http://orcid.org/0000-0002-9391-8122
Barbara GardellaDepartment of Obstetrics and Gynecology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Alessandro BorghesiHost-Pathogen Interaction Group and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.ORCID http://orcid.org/0000-0002-8773-9144
Nicole PrinceChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8506-1122
Jessica Lasky-SuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6236-4705
Michael R WilsonDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8705-5084
Marcelle I CedarsDepartment of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Joshua E EliasChan Zuckerberg Biohub San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8063-3259
Tippi C MacKenzieDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Joseph L DeRisiDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA. joe@derisilab.ucsf.edu.ORCID http://orcid.org/0000-0002-4611-9205

Funding

Better utilization of omics data to inform precision medicine for asthma throughout the life courseR01HL169300 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI JESSICA A LASKY-SU · 2024 to 2026
$2.3M
Molecular understanding of self immunity in the brainK99NS117800 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANDEL-BREHM, CALEIGH · 2020 to 2021
$211k
Endometriosis autoantibody target discovery and functional validation.F30HD117526 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Hannah Kortbawi · 2025 to 2026
$89k
Burroughs Wellcome Fund (BWF) 2022 NextGen Pregnancy AwardBurroughs Wellcome Fund (BWF) 2023 NextGen Pregnancy AwardDivision of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) K08AI137209Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) K08AI141728Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) K99AI182451Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) R01HD111582U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 5T32HD098057U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) F30HD117526U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL169300U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) K99NS117800
6 · The paper itself

Abstract

Preterm birth is associated with breakdown of maternal-fetal tolerance and remains the leading cause of global mortality in young children. However, the role of self-reactive antibodies has been limited to a handful of pathogenic allo- and autoantibodies linked to pregnancy complications. Here we identify a shared autoreactive signature of pregnancy in pregnant sera (n = 2,719) relative to never-pregnant controls (n = 130), using proteome-wide autoantibody profiling. Across eight human pregnancy cohorts, we define autoreactivities associated with preterm birth by comparing preterm (n = 688) and term (n = 1,505) pregnancies. Within the signature, antibodies to IL1 receptor antagonist (IL1RA) induce resorption, inflammation and vascular malperfusion in pregnant mice. IL1RA localizes to placental endothelial adherens junctions, suggesting a role in vascular integrity. These findings identify a term pregnancy humoral immune program and shared changes preceding preterm delivery, including anti-IL1RA, which may have direct pathogenic consequences.

Identifiers

PMID42875547

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