Evidence map›Paper›PMID 42875502›Full record

ArticleNature2026

A microexon regulatory code reveals autism-linked genetic variation.

Guillermo E Parada, Hannes Bretschneider, Jack Daiyang Li, Jacob L Fine, Steven J Dupas, Jonathan D Ellis, Ulrich Braunschweig, Sophie Bonnal, Taykhoom Dalal, Worrawat Engchuan and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Guillermo E Parada *Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Hannes Bretschneider *Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Jack Daiyang LiDonnelly Centre, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0009-0008-6707-1117
Jacob L FineDonnelly Centre, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0009-0003-1611-5398
Steven J DupasDonnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Jonathan D EllisDonnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Ulrich BraunschweigDonnelly Centre, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-6653-0926
Sophie BonnalCentre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.
Taykhoom DalalComputational Biology and Medicine Program, Weill-Cornell Graduate School, New York, NY, USA.ORCID http://orcid.org/0000-0003-3944-631X
Worrawat EngchuanThe Centre for Applied Genomics and Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-6138-1925
Mehdi ZarreiThe Centre for Applied Genomics and Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Wei WeiDevelopmental, Stem Cell & Cancer Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Nadia ZafarDepartment of Biochemistry, Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Martin HembergThe Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8895-5239
Liliana AttisanoDepartment of Biochemistry, Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-4824-2642
James EllisDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Manuel IrimiaCentre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2179-2567
Michael WainbergProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-6061-0239
Brett TrostDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Stephen W SchererDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-8326-1999
Quaid D MorrisDonnelly Centre, University of Toronto, Toronto, Ontario, Canada. morrisq@mskcc.org.ORCID http://orcid.org/0000-0002-2760-6999
Benjamin J BlencoweDonnelly Centre, University of Toronto, Toronto, Ontario, Canada. b.blencowe@utoronto.ca.ORCID http://orcid.org/0000-0002-4461-0340

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuronal microexons are a highly conserved class of alternative splicing events enriched in genes with critical functions in nervous system biology

Identifiers

PMID42875502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.