Evidence map›Paper›PMID 42875493›Full record

ArticleNature2026

Modelling mouse embryogenesis from chemically induced totipotent stem cells.

Hua Wu, Yanyan Hu, Hanzhi Yu, Nana Huang, Lu Shi, Menghan Gao, Xinghan Du, Xue Lu, Yuxia Zhang, Xiya Sun and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Hua WuNew Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0002-9159-4267
Yanyan Hu *Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0005-4867-0593
Hanzhi Yu *New Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Nana Huang *Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Lu ShiCRE Life Institute, Beijing, China.
Menghan GaoNew Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Xinghan DuNew Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Xue LuAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-2808-8839
Yuxia ZhangNew Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Xiya SunDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Xiaoqing XuNew Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Zhimin LiuNew Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Junsong YuanNew Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.ORCID http://orcid.org/0009-0005-8922-2201
Wei ZhouNew Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Qiliang ShaoNew Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Dan WangNew Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Yangyu ZhaoDepartment of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Tianhua MaNew Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China. matianhua@tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-4707-263X
Sheng DingNew Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China. shengding@tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-3354-1263

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to faithfully initiate embryogenesis from a single, induced non-germline cell type, akin to the totipotent blastomeres, remains a considerable challenge in developmental and synthetic biology

Identifiers

PMID42875493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.