Evidence map›Paper›PMID 42875487›Full record

ArticleNature2026

Computational design of metalloproteases.

Anqi Chen, Kejia Wu, Hojae Choi, Preetham Venkatesh, Samuel J Pellock, Nikita Hanikel, Hojeong Shin, Declan Evans, Kieran Didi, Lars L Schaaf and 18 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Anqi Chen *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9857-0594
Kejia Wu *Department of Biochemistry, University of Washington, Seattle, WA, USA. kejiawu@uw.edu.ORCID http://orcid.org/0000-0002-4532-4290
Hojae ChoiDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0009-0004-8035-1552
Preetham VenkateshDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Samuel J PellockDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7557-7985
Nikita HanikelDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Hojeong ShinDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Declan EvansDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Kieran DidiInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6839-3320
Lars L SchaafCavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-1935-236X
Cristina Díaz-PerlasInstitut Químic de Sarrià, Universitat Ramon Llull, Barcelona, Spain.ORCID http://orcid.org/0000-0002-9552-3896
Brian CoventryDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6910-6255
Donghyo KimDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8097-3675
Seth M WoodburyDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-0510-8240
Pengfei JiDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-8109-7929
Shingo HondaDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9403-6631
Asim K BeraDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9473-2912
Hannah NguyenDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9696-4004
Alex KangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5487-0499
Yanqing WangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0009-0000-2223-2687
Xinting LiDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Stacey GerbenDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-0313-6248
Lemuel ChangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Xiao YanMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Benjamí Oller-SalviaInstitut Químic de Sarrià, Universitat Ramon Llull, Barcelona, Spain.
Anthony A HymanDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-0851-704X
Donald HilvertLaboratory of Organic Chemistry, ETH Zurich, Zurich, Switzerland. hilvert@ethz.ch.ORCID http://orcid.org/0000-0002-3941-621X
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID http://orcid.org/0000-0001-7896-6217

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

De novo design of enzymes that cleave amide bonds represents a major challenge

Identifiers

PMID42875487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.