Evidence map›Paper›PMID 42875435›Full record

ArticleCell death & disease2026

Mesenchymal stromal cells immunosuppress osteoarthritis synovial fluid modulated monocytes via IL-6 and CCL2.

Mozhgan Rasti, Aida Feiz Barazandeh, Shahrzad Nouri, Kevin P Robb, Rachel Low, Oreoluwa Kolade, Kevin Fan, Rajiv Gandhi, Sowmya Viswanathan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mozhgan RastiSchroeder Arthritis Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.
Aida Feiz BarazandehSchroeder Arthritis Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.
Shahrzad NouriSchroeder Arthritis Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.
Kevin P RobbSchroeder Arthritis Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.
Rachel LowSchroeder Arthritis Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.
Oreoluwa KoladeSchroeder Arthritis Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.
Kevin FanSchroeder Arthritis Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.
Rajiv GandhiSchroeder Arthritis Institute, University Health Network, Toronto, ON, M5T 0S8, Canada.
Sowmya ViswanathanSchroeder Arthritis Institute, University Health Network, Toronto, ON, M5T 0S8, Canada. sowmya.viswanathan@uhn.ca.ORCID http://orcid.org/0000-0002-4552-0179

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-166089
6 · The paper itself

Abstract

Mesenchymal stromal cell (MSC) interactions with monocytes/macrophages are central to their therapeutic effects in knee osteoarthritis (KOA); however, mechanisms of these interactions are not fully understood. We hypothesize that MSC soluble factors, particularly interleukin-6 (IL-6) and C-C motif chemokine ligand (CCL2) modulate monocytes in KOA environment. Using healthy donor CD14

Indexed as

Chemokine CCL2Interleukin-6Mesenchymal Stem CellsMonocytesOsteoarthritisOsteoarthritis, KneeSynovial FluidCulture Media, ConditionedHumansJNK Mitogen-Activated Protein KinasesLipopolysaccharide ReceptorsNF-kappa BPhagocytosisSignal TransductionSTAT3 Transcription FactorTumor Necrosis Factor-alphaCCL2 protein, humanChemokine CCL2Culture Media, ConditionedIL6 protein, humanInterleukin-6JNK Mitogen-Activated Protein KinasesLipopolysaccharide ReceptorsNF-kappa BSTAT3 protein, humanSTAT3 Transcription FactorTumor Necrosis Factor-alpha

Identifiers

PMID42875435
PMCPMC13669379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.