Evidence map›Paper›PMID 42875426›Full record

ArticleNature communications2026

Identification of a spatially organized TREM2-associated permissive macrophage niche in human pulmonary tuberculosis alveolar pneumonia.

Rosane M B Teles, Chaouki Benabdessalem, Jonathan Perrie, Cenfu Wei, Julie West, Bruno J de Andrade Silva, Priscila R Andrade, Lilah A Mansky, Prajan Divaka, Linda Fischbacher and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Rosane M B TelesDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2908-3244
Chaouki BenabdessalemLaboratory of Transmission, Control and Immunobiology of Infections, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.ORCID http://orcid.org/0000-0001-7309-6814
Jonathan PerrieDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA, USA.
Cenfu WeiNorthwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-3368-4974
Julie WestDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0004-6089-8948
Bruno J de Andrade SilvaDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Priscila R AndradeDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Lilah A ManskyDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Prajan DivakaBruker Spatial Biology, Bothell, WA, USA.
Linda FischbacherDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Karen LamDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4635-7008
Feiyang MaDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6260-0787
Yiqian GuDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0000-9131-6278
Kimia RateghDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Madeline BrownDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Aparna PillaiDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Kapongo LumambaAfrica Health Research Institute, Durban, South Africa.
Threnesan NaidooAfrica Health Research Institute, Durban, South Africa.
Samuel M FrenchDepartment of Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-7611-881X
Emna RomdhaneDepartment of Pathology, Charles Nicolle Hospital, Tunis, Tunisia; LR23ES02, Faculté de Médecine de Tunis, Université de Tunis El Manar, Tunis, Tunisia.
Mohamed-Ridha BarboucheLaboratory of Transmission, Control and Immunobiology of Infections, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
Eynav KlechevskyDepartment of Pathology & Immunology, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-6121-1571
Marco ColonnaDepartment of Pathology & Immunology, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-5222-4987
Adrie J C SteynAfrica Health Research Institute, Durban, South Africa.ORCID http://orcid.org/0000-0001-9177-8827
Steven J BensingerDepartment of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9657-4206
Daniel L BarberLaboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-7008-7509
Soumaya RammehDepartment of Pathology, Charles Nicolle Hospital, Tunis, Tunisia; LR23ES02, Faculté de Médecine de Tunis, Université de Tunis El Manar, Tunis, Tunisia.ORCID http://orcid.org/0000-0003-0366-4630
Parambir S DulaiNorthwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9514-2321
Bryan D BrysonMassachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1716-6712
Matteo PellegriniDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9355-9564
John T BelisleDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
Barry R BloomHarvard T.H. Chan School of Public Health, Boston, MA, USA.
Robert L ModlinDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. rmodlin@mednet.ucla.edu.ORCID http://orcid.org/0000-0003-4720-031X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary tuberculosis (TB), caused by lung infection with Mycobacterium tuberculosis (Mtb), often manifests both alveolar pneumonia and aggregation of immune cells containing Mtb, termed granulomas, within the same lung. Here, we integrate spatial transcriptomics, single-cell RNA sequencing, high-resolution imaging, and functional assays of lung biopsies from four men with pulmonary TB to compare alveolar pneumonia with adjacent granulomas. We find that alveolar TB pneumonia is enriched for TREM2⁺ lipid-laden macrophages characterized by increased lipid metabolism gene expression, reduced T cell infiltration, attenuated antimicrobial gene expression, and abundant Mtb transcripts and antigens. By contrast, neighboring granulomas exhibit organized lymphoid architecture and robust antimicrobial programs. In vitro, Mtb lipids induce TREM2 expression, activate TREM2-DAP12 signaling, and promote lipid droplet accumulation in primary human monocyte-derived macrophages (MDM). Furthermore, TREM2

Indexed as

MacrophagesMembrane GlycoproteinsReceptors, ImmunologicTuberculosis, PulmonaryGranulomaHumansLipid MetabolismLungMaleMycobacterium tuberculosisSignal TransductionMembrane GlycoproteinsReceptors, ImmunologicTREM2 protein, human

Identifiers

PMID42875426
PMCPMC13669344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.