Evidence map›Paper›PMID 42875424›Full record

ArticleNature communications2026

Antagonistic roles of histone H3 lysine methyltransferases dictate tumor immune surveillance.

Amy C Gladstein, Akino Mercy Charles Solomon, Carson D Poltorack, Sharan Venkatesh, Keren M Adler, Maggie R Robertson, Stephanie Stransky, Valerie M Irizarry-Negron, Dain A Ruiz, Dingwen Tao and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Amy C GladsteinDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3318-6695
Akino Mercy Charles Solomon *Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Carson D Poltorack *Cell and Molecular Biology Graduate Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sharan VenkateshDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Keren M AdlerDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Maggie R RobertsonDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Stephanie StranskyDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-0844-2754
Valerie M Irizarry-NegronDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8542-726X
Dain A RuizDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6080-8288
Dingwen TaoDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nelson F FreeburgDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Simone SidoliDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-9073-6641
Irfan A AsanganiDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-5381-1702
Sydney M ShafferCell and Molecular Biology Graduate Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3539-9886
David M FeldserDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. dfeldser@upenn.edu.ORCID http://orcid.org/0000-0001-5975-864X

Funding

U.S. Department of Defense (United States Department of Defense) W81XWH2210008U.S. Department of Defense (United States Department of Defense) W81XWH2210742U.S. Department of Health & Human Services | NIH | Division of Loan Repayment (DLR) 2-T32-CA-15299-15U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01-CA262619U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01-CA276350U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01-CA279698,
6 · The paper itself

Abstract

SETD2 is a critical tumor suppressor in lung cancer that catalyzes histone H3 lysine 36 (H3K36) trimethylation. Oncogenic histone H3 alleles, including H3

Indexed as

Histone-Lysine N-MethyltransferaseHistonesImmunologic SurveillanceLung NeoplasmsAnimalsCell Line, TumorEnhancer of Zeste Homolog 2 ProteinGene Expression Regulation, NeoplasticHumansLysineMethylationMiceProto-Oncogene Proteins p21(ras)Repressor ProteinsRNA, Double-StrandedEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseHistone-Lysine N-MethyltransferaseHistonesHras protein, mouseLysineProto-Oncogene Proteins p21(ras)Repressor ProteinsRNA, Double-StrandedSETD2 protein, humanSETD2 protein, mouse

Identifiers

PMID42875424
PMCPMC13669384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.