VEGFR-dependent signaling contributes to postnatal brown adipose tissue development in Syrian hamsters.

Khaled Mahmud Sujan, Yukino Tamakoshi, Bong Soo Seok, Zibo Yang, Shucheng Xu, Mohamed Elfeky, Mira Kato-Suzuki, Yuko Okamatsu-Ogura

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Article in The journal of physiological sciences : JPS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Khaled Mahmud SujanLaboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan; Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, 2202, Bangladesh.

Yukino TamakoshiLaboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan.

Bong Soo SeokLaboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan.

Zibo YangLaboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan.

Shucheng XuLaboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan.

Mohamed ElfekyLaboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan; Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, 21526, Egypt.

Mira Kato-SuzukiLaboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan.

Yuko Okamatsu-OguraLaboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan. Electronic address: y-okamatsu@vetmed.hokudai.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In most mammals, brown adipose tissue (BAT) forms before or soon after birth, whereas Syrian hamsters are born without BAT, which develops postnatally through the proliferation and differentiation of brown adipocyte progenitors. Since sympathetic innervation and vascularization are critical for BAT function, we examined their roles in postnatal BAT formation using interscapular adipose tissue from postnatal day (P) 6-14 hamsters. Putative progenitor-like cells were sparsely distributed at P6 and became progressively more abundant throughout the tissue with postnatal age. Sympathetic innervation emerged after P8, whereas blood vessels were detectable from P6 and increased with age during BAT development. Inhibition of vascular endothelial growth factor receptor (VEGFR) signaling by SU5416 significantly reduced cell proliferation and UCP1 expression. These findings suggest that VEGFR-dependent signaling contributes to postnatal BAT development in Syrian hamsters.

Indexed as

AngiogenesisBrown adipose tissueCell proliferationSympathetic innervationSyrian hamster

Identifiers

PMID42874135

DOI10.1016/j.jphyss.2026.100106

PMCPMC13683434

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