Evidence map›Paper›PMID 42873986›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2026

The neogenin-hemojuvelin axis in murine liver is crucial for hepcidin expression.

Caroline A Enns, Shall Jue, Bethel Demissu, An-Sheng Zhang

Abstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Caroline A EnnsDepartment of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, Oregon, United States.ORCID 0000-0002-5852-3766
Shall JueDepartment of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, Oregon, United States.
Bethel DemissuDepartment of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, Oregon, United States.ORCID 0009-0009-2775-1983
An-Sheng ZhangDepartment of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, Oregon, United States.ORCID 0000-0002-0683-946X

Funding

ROLES OF NEOGENIN AND MATRIPTASE-2 IN IRON HOMEOSTASISR01DK102791 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI CAROLINE ENNS, An-Sheng Zhang · 2015 to 2026
$6.1M
Regulation of hepatic hepcidin expression by transferrin receptor-2R01DK125318 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI ENNS, CAROLINE · 2021 to 2024
$2.1M
NIDDK NIH HHS R01 DK102791NIDDK NIH HHS R01 DK125318
6 · The paper itself

Abstract

Neogenin (NEO1) is a ubiquitously expressed, multifunctional receptor that binds hemojuvelin (HJV); both proteins are essential components within hepatocytes for maintaining systemic iron homeostasis. Previous research established that the targeted ablation of hepatic

Indexed as

GPI-Linked ProteinsHemochromatosis ProteinHepcidinsLiverMembrane ProteinsAnimalsHepatocytesIronMiceMice, Inbred C57BLMice, KnockoutSignal TransductionGPI-Linked ProteinsHamp protein, mouseHemochromatosis ProteinHepcidinsHJV protein, mouseIronMembrane Proteinsneogeninhemojuvelinhepcidiniron homeostasisliverneogenin

Identifiers

PMID42873986
PMCPMC13670174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.