Vitamin D binding protein in ventral CA3 of the hippocampus drives stress-induced depression.

Yan Kong, Zihan Huang, Cuiju Zeng, Yinghan Xu, Zhijun Zhang

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Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Yan KongDepartment of Neurology in Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Institute of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Southeast University, Nanjing, Jiangsu, China.ORCID 0009-0005-2621-4730

Zihan HuangDepartment of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing, Jiangsu, China.

Cuiju ZengDepartment of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing, Jiangsu, China.

Yinghan XuDepartment of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing, Jiangsu, China.

Zhijun ZhangDepartment of Neurology in Affiliated Zhongda Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Institute of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Southeast University, Nanjing, Jiangsu, China.ORCID 0000-0001-5480-0888

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ventral hippocampus plays a crucial role in regulating emotional and motivated behaviors. However, the molecular mechanisms underlying its dysfunction in major depressive disorder (MDD) remain poorly understood. Here, we identified elevated expression of vitamin D binding protein (VDBP) in the hippocampi of chronic unpredictable mild stress (CUMS)-susceptible mice, which correlated with the severity of depression-like behaviors. Notably, VDBP up-regulation was specifically in ventral CA3 excitatory (vCA3

Indexed as

CA3 Region, HippocampalDepressionStress, PsychologicalAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Disease Models, AnimalMaleMiceNeuronsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesCalcium-Calmodulin-Dependent Protein Kinase Type 2Camk2a protein, mousePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinases

Identifiers

PMID42873880

DOI10.1126/sciadv.aeh9563

PMCPMC13666054

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.