In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
36 authors.
Trisha BansalDepartment of Pharmacology and Regenerative Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-7047-4389 Min-Kyu LeeQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-8770-585X Courtney ColemanDepartment of Pharmacology and Regenerative Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0009-0009-3061-3389 Dane HintermuellerQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Yaner ChenQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Varsha SreekanthDepartment of Biochemistry and Molecular Genetics, University of Illinois, College of Medicine, Chicago, IL 60607, USA.
Chad R HaneyCenter for Advanced Molecular Imaging, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-5981-2925 Olga A KarginovaDepartment of Biochemistry and Molecular Genetics, University of Illinois, College of Medicine, Chicago, IL 60607, USA.ORCID 0009-0006-0250-2030 Jacob MatscheDepartment of Pharmacology and Regenerative Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-4743-0297 Shaluah VijethDepartment of Biochemistry and Molecular Genetics, University of Illinois, College of Medicine, Chicago, IL 60607, USA.ORCID 0000-0003-0903-6651 Farah YousefDepartment of Biochemistry and Molecular Genetics, University of Illinois, College of Medicine, Chicago, IL 60607, USA.
Kento YamagishiQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-2209-7910 Jiheon KangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0009-0009-4390-787X Kaitlyn MowryQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0009-0009-1096-1976 Minsung KimQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-2468-2061 Sophianne LohQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0009-0006-6838-7549 Sachin ClarkQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
Huong HuynhQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0009-0002-6022-1377 Youngdo KimQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0009-0000-0553-2995 Kaiqing ZhangDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
Haohui ZhangDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-8432-3672 Shupeng LiDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-8723-9369 Yuanting WeiDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-5779-5332 Yuru LiuDepartment of Pharmacology and Regenerative Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.
Anthony R BanksQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0509-0370 Odile DavidDepartment of Pathology, University of Illinois Hospital & Health Sciences System, Chicago, IL 60612, USA.ORCID 0000-0002-6539-2573 Peter T TothDepartment of Pharmacology and Regenerative Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-2168-0124 Yonggang HuangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0483-8359 Cameron H GoodQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0183-4854 John A RogersQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-3830-5980 Andrei V KarginovDepartment of Pharmacology and Regenerative Medicine, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-2370-6383 Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MSynthetic Biology and Optogenetics CoreP01HL151327 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REHMAN, JALEES · 2021 to 2025
$11.8MIntegrated three-dimensional (3D) microscopy for a spatial pharmacology atlas of macromolecular drugs in the tissue microenvironmentR35GM142743 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEE, STEVE SEUNG-YOUNG · 2021 to 2025
$2.3MRegulation of endothelial cell invasion, migration and cell junction plasticityR35GM145318 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ANDREI V KARGINOV · 2022 to 2026
$2.2MOptogenetic Control of Tumor Initiation and Tumor Progression in vivoR33CA258012 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARGINOV, ANDREI V, REHMAN, JALEES · 2022 to 2024
$1.2MNCI NIH HHS P30 CA060553NCI NIH HHS R33 CA258012NHLBI NIH HHS P01 HL151327NIGMS NIH HHS R35 GM142743NIGMS NIH HHS R35 GM145318
6 · The paper itselfAbstract
Effective modeling of chronic human diseases in vivo requires precise spatiotemporal regulation of molecular processes at defined tissue locations. Optogenetic and optoelectronic tools can provide such control but targeting internal organs such as the lungs remain challenging. To address this, we developed E-LightR-Cre recombinase, enabling precise, spatially restricted gene activation with no dark-state activity and robust blue light responsiveness. To achieve local activation of E-LightR-Cre in specific organ sites, we engineered wireless, fully implantable optoelectronic devices enabling focal illumination of murine lungs with no discernible organ damage. The size of the activated area is controlled by modulating light intensity and duration. Using implanted optoelectronic devices, we activated E-LightR-Cre in a selected area of mouse lungs and achieved local regulation of targeted genes. Light-regulated expression of the oncogenic KRas-G12D mutant in mouse lungs induced local formation of oncogenic lesions. These results show that our protein engineering and adaptable optoelectronic approaches enable facile application of optogenetic tools for locally controlled disease modeling in vivo.
Indexed as
IntegrasesModels, GeneticOptogeneticsWireless TechnologyAnimalsLungMiceProto-Oncogene Proteins p21(ras)Cre recombinaseIntegrasesProto-Oncogene Proteins p21(ras)
Identifiers
PMID42873865
PMCPMC13665946
What OpenQuestion holds
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