Evidence map›Paper›PMID 42873853›Full record

ArticleScience advances2026

A transcriptional cofactor GRIP1 drives PPARγ DNA binding and p300-dependent enhancer activity during homeostatic macrophage polarization.

Marija Dacic, William J Stein, Ruoxi Yuan, Dinesh K Deochand, Joshua K Morrison, Ketsia Seide, Yurii Chinenov, Inez Rogatsky

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marija DacicHospital for Special Surgery Research Institute, The David Rosensweig Genomics Center, New York, NY, USA.ORCID 0009-0005-9624-5049
William J SteinHospital for Special Surgery Research Institute, The David Rosensweig Genomics Center, New York, NY, USA.ORCID 0009-0004-9243-4259
Ruoxi YuanHospital for Special Surgery Research Institute, The David Rosensweig Genomics Center, New York, NY, USA.ORCID 0000-0002-8719-341X
Dinesh K DeochandHospital for Special Surgery Research Institute, The David Rosensweig Genomics Center, New York, NY, USA.ORCID 0000-0002-7395-9250
Joshua K MorrisonHospital for Special Surgery Research Institute, The David Rosensweig Genomics Center, New York, NY, USA.ORCID 0000-0003-4174-6338
Ketsia SeideHospital for Special Surgery Research Institute, The David Rosensweig Genomics Center, New York, NY, USA.ORCID 0009-0009-0405-953X
Yurii ChinenovHospital for Special Surgery Research Institute, The David Rosensweig Genomics Center, New York, NY, USA.ORCID 0000-0001-5226-8541
Inez RogatskyHospital for Special Surgery Research Institute, The David Rosensweig Genomics Center, New York, NY, USA.ORCID 0000-0003-3514-5077

Funding

Glucocorticoid-regulated transcription networks in macrophage biologyR01DK099087 · NIDDK · HOSPITAL FOR SPECIAL SURGERY · PI INEZ ROGATSKY · 2014 to 2026
$6.0M
Post-Initiation control of transcription in inflammatory macrophagesR01AI148129 · NIAID · HOSPITAL FOR SPECIAL SURGERY · PI ROGATSKY, INEZ · 2020 to 2024
$3.0M
NIAID NIH HHS R01 AI148129NIDDK NIH HHS R01 DK099087
6 · The paper itself

Abstract

Homeostatic macrophages maintain tissue health and resolve inflammation. Upon sustained exposure to type II cytokine IL4, transcription factors STAT6, KLF4, EGR2 and a ligand-regulated nuclear receptor PPARγ orchestrate the M2

Indexed as

DNAE1A-Associated p300 ProteinEnhancer Elements, GeneticMacrophagesNerve Tissue ProteinsPPAR gammaAdaptor Proteins, Signal TransducingAnimalsEnhancer RNAsGene Expression RegulationHomeostasisKruppel-Like Factor 4MiceNuclear Receptor Co-Repressor 2PPAR-gamma AgonistsProtein BindingAdaptor Proteins, Signal TransducingDNAE1A-Associated p300 ProteinEnhancer RNAsEp300 protein, mouseGrip1 protein, mouseKlf4 protein, mouseKruppel-Like Factor 4Nerve Tissue ProteinsNuclear Receptor Co-Repressor 2PPAR gammaPPAR-gamma AgonistsRosiglitazone

Identifiers

PMID42873853
PMCPMC13666059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.