ArticleScience advances2026
SPRIZ (CCDC127) protein conserved in deuterostome animals is a rigid OMM-IMM tether that locally sets mitochondrial IMS volume.
Raman Shulinski, Roman Loban, Danny Farhat, Benjamín Cartes-Saavedra, Matthew J Magda, Pavel Kotchetkov, Victoria Caminiti, Linda David, Yuri I Wolf, Conor O'Dwyer and 8 more
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In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
18 authors.
Raman ShulinskiGraduate program in Biochemistry, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.ORCID 0009-0004-2428-6098 Roman LobanMitochondria Biology Laboratory, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Danny FarhatGraduate program in Biochemistry, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0002-9600-7973 Benjamín Cartes-SaavedraMitoCare Center, Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-2753-5780 Matthew J MagdaOttawa Institute for Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Pavel KotchetkovGraduate Program in Neurobiology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Victoria CaminitiMitochondria Biology Laboratory, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Linda DavidMitochondria Biology Laboratory, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Yuri I WolfComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0247-8708 Conor O'DwyerDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Morgan FullertonDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0002-7221-306X Yan BurelleDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0001-9379-146X Jyh-Yeuan Eric LeeDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0003-1799-2416 Eugene V KooninComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3943-8299 György HajnóczkyMitoCare Center, Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0003-3813-2570 Mary-Ellen HarperOttawa Institute for Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Luca PellegriniMitochondria Biology Laboratory, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0002-4235-7708 Funding
Mitochondrial Calcium Uniporter in Signaling and DynamicsR01GM151536 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI Gyorgy Hajnoczky · 2023 to 2026
$1.7MNIGMS NIH HHS R01 GM151536
6 · The paper itselfAbstract
The double-membrane nature of mitochondria generates an intermembrane volume through which ions, reactive oxygen species, and metabolites must flux to reach the matrix or cytosol, but whether this volume is a genetically specified structure remains unknown. We identify SPRIZ (spatial regulator of the intermembrane zone), the product of
Indexed as
Mitochondrial MembranesMitochondrial ProteinsAnimalsCryoelectron MicroscopyMiceMitochondriaMitochondrial Proteins
Identifiers
PMID42873847
PMCPMC13666014
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