ArticleScience advances2026
Integrative multi-omics reveals CUL4B as a modulator of macrophage pyroptosis and innate defense against
Abstract read
In one paragraph
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors.
Fatemeh AskarianDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID 0000-0002-7438-4671
Daniel SunDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID 0000-0001-7119-6045
Jasmine TatDepartment of Bioengineering, University of California San Diego, School of Medicine, La Jolla, CA, USA.
James T SorrentinoDepartment of Bioengineering, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Armin KoushaDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID 0009-0003-0461-9951
Consuelo SaucedaSkaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA, USA.ORCID 0000-0002-1487-6631
Siri YendluriDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Yu YanDepartment of Pathology and Laboratory Medicine, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, NY, USA.
Ka Pui Sharon YauDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID 0000-0002-4250-5635
Helen MassonDepartment of Bioengineering, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Jacob WozniakSkaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA, USA.
Kristin PettersenResearch Laboratory, Nordland Hospital, Bodø, Norway.ORCID 0009-0006-0262-5372
Natalie ChavarriaDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID 0009-0007-0581-9620
Ella McLarenDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID 0000-0002-9830-033X
Hunter GageDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Alexandria HoffmanDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID 0000-0002-8208-8995
Stanley DavisDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID 0009-0007-0650-7522
Chih-Ming TsaiDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID 0000-0001-7305-7401
Jonathan MonkDepartment of Bioengineering, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Angela MeierDepartment of Anesthesiology, Division of Critical Care, University of California San Diego, La Jolla, CA, USA.
George SakoulasDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Tom Eirik MollnesResearch Laboratory, Nordland Hospital, Bodø, Norway.ORCID 0000-0002-5785-802X
Gustav Vaaje-KolstadFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.ORCID 0000-0002-3077-8003
Ingrid CornaxDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Pengbo ZhouDepartment of Pathology and Laboratory Medicine, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, NY, USA.
Mona JohannessenDepartment of Medical Biology, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway.ORCID 0000-0003-4604-8600
David J GonzalezSkaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA, USA.ORCID 0000-0003-1423-5970
Nathan E LewisDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Victor NizetDepartment of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID 0000-0003-3847-0422
Funding
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9MUnraveling the mammalian secretory pathway through systems biology and algorithm developmentR35GM119850 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEWIS, NATHAN ENOCH · 2016 to 2025
$4.3MUpstream and downstream targeting of the SPOP ubiquitin signaling pathway in prostate cancerR01CA287724 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Christopher E Barbieri, Pengbo Zhou · 2024 to 2026
$3.6MHarnessing the CRL4 ubiquitin ligase for antagonizing colorectal carcinogenesisR01CA213992 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, PENGBO · 2017 to 2021
$2.7MSurprising Efficacy of Discounted Antibiotics vs. MDR Gram-Negative Pathogens Occurring Through Innate Immune SensitizationR01AI145310 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMARASWAMY, MONIKA, NIZET, VICTOR · 2020 to 2023
$1.9MImmCellFIE: producing high-resolution snapshots of the functions of immune cellsUH2AI153029 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEWIS, NATHAN ENOCH, ROBASKY, KIMBERLY JOAN · 2020 to 2021
$445kNCI NIH HHS P30 CA023100NCI NIH HHS R01 CA213992NCI NIH HHS R01 CA287724NIAID NIH HHS R01 AI145310NIAID NIH HHS UH2 AI153029NIGMS NIH HHS R35 GM119850
Abstract
PubMed holds no abstract for this paper.
Indexed as
Cullin ProteinsImmunity, InnateMacrophagesPyroptosisStaphylococcal InfectionsStaphylococcus aureusAnimalsHost-Pathogen InteractionsHumansInflammasomesMethicillin-Resistant Staphylococcus aureusMiceMultiomicsProteomicsCullin ProteinsInflammasomes
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.