Evidence map›Paper›PMID 42873742›Full record

ArticleHealth promotion international2026

Dr Reddit? The quality and accuracy of information about IVF add-ons on Reddit.

Sara Attinger, Joscelyn Gan, Amandi Perera, Nikka Milani, Kim Doyle, Michelle Steeper, Jack Wilkinson, Ektoras X Georgiou, Tammy Hoffmann, Sarah Lensen

Abstract read
In one paragraph

Article in Health promotion international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sara AttingerObstetrics, Gynaecology and Newborn Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Level 7 Royal Women's Hospital, Victoria 3052, Australia.
Joscelyn GanMelbourne Medical School, University of Melbourne, Grattan Street, Parkville, Victoria 3010, Melbourne, Australia.
Amandi PereraObstetrics, Gynaecology and Newborn Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Level 7 Royal Women's Hospital, Victoria 3052, Australia.
Nikka MilaniSt Vincent's Hospital Melbourne, Melbourne, Australia.
Kim DoyleMelbourne Data Analytics Platform, School of Computing and Information Systems, Faculty of Engineering and Information Technology, University of Melbourne, Level 8, Melbourne Connect, 700 Swanston Street, Carlton, Victoria 3053, Melbourne, Australia.
Michelle SteeperObstetrics, Gynaecology and Newborn Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Level 7 Royal Women's Hospital, Victoria 3052, Australia.
Jack WilkinsonCentre for Biostatistics, Manchester Academic Health Science Centre, Division of Population Health, Health Services Research and Primary Care, University of Manchester, Jean McFarlane Building, Oxford Road, Manchester M13 9PL, Manchester, United Kingdom.ORCID 0000-0003-3513-4677
Ektoras X GeorgiouObstetrics, Gynaecology and Newborn Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Level 7 Royal Women's Hospital, Victoria 3052, Australia.
Tammy HoffmannInstitute for Evidence-Based Healthcare, Bond University, Building 5, Level 4, 14 University Drive, Robina, Queensland 4226, Gold Coast, Australia.
Sarah LensenObstetrics, Gynaecology and Newborn Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Level 7 Royal Women's Hospital, Victoria 3052, Australia.ORCID 0000-0002-1694-1142

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IVF add-ons are optional tests, treatments or procedures offered in addition to standard IVF, often at additional cost and with uncertain evidence of benefit. In a commercialized fertility sector, patients must make complex reproductive decisions while navigating variable clinical information, online advice and peer-to-peer narratives. This study examined Reddit as a digital health environment shaping access to information and decision-making about IVF add-ons. Posts and comments from the r/IVF subreddit were extracted from 14 October to 13 November 2024, filtered using IVF add-on keywords, and manually reviewed for eligibility. Eligible content included anecdotes, claims about benefit or lack of benefit, and/or recommendations to use or avoid an add-on. Accuracy of claims was independently assessed by two researchers against evidence-based sources, including Cochrane reviews. Of 32 420 posts and comments screened, 1498 were eligible, comprising 2011 relevant statements: anecdotes (n = 1414), claims (n = 250), and recommendations (n = 347). The most frequently mentioned add-ons were preimplantation genetic testing for aneuploidy, aspirin, antioxidants, acupuncture, and growth hormone. Anecdotes more commonly described success than failure (64% vs 36%). Most claims asserted benefit (161/250, 64%), and most benefit claims were unsupported or contradicted by robust evidence (111/161, 69%). Recommendations overwhelmingly encouraged add-on use (280/347, 81%), despite limited supporting evidence. Online forums can provide valuable peer support, but may also amplify unsubstantiated benefit claims and commercially aligned treatment norms. Accessible, independent, evidence-based digital resources are needed to strengthen reproductive autonomy and informed decision-making in women's reproductive health.

Indexed as

Fertilization in VitroDecision MakingDigital MediaFemaleHumansPreimplantation DiagnosisIVF add-onsonlinepeersRedditsocial media

Identifiers

PMID42873742
PMCPMC13665465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.