ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026
Dodonaea viscosa-derived gold nanoparticles exhibit differential effects across breast cell models and intracellular localisation in MDA-MB-231 cells.
Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Breast cancer remains a major malignancy, with triple-negative breast cancer (TNBC) representing an aggressive subtype with limited therapeutic options. This study investigated the synthesis, physicochemical properties, and biological activity of Dodonaea viscosa-derived gold nanoparticles (DV-AuNPs). Synthesis was optimised for reaction temperature, extract concentration, and extract-to-gold chloride ratio. DV-AuNPs were characterised using ultraviolet-visible spectroscopy, dynamic light scattering, X-ray diffraction, Fourier-transform infrared spectroscopy, and electron microscopy, and their colloidal stability was assessed in biologically relevant media over two weeks. The nanoparticles were predominantly spherical (19.6 ± 3.6 nm) and exhibited surface functionalisation with plant-derived compounds. Cellular metabolic activity/viability assessment revealed differential responses across breast-cell models: MDA-MB-231 cells demonstrated concentration-dependent sensitivity to DV-AuNP exposure, whereas MCF-7 and non-tumorigenic MCF-12A cells were comparatively less responsive under the tested conditions. In MDA-MB-231 cells, DV-AuNP treatment markedly suppressed clonogenic capacity, while functional assays revealed limited effects on migration and epithelial-to-mesenchymal transition (EMT)-associated proteins. Transmission electron microscopy demonstrated intracellular localisation of electron-dense particles consistent with DV-AuNPs. To the best of our knowledge, this study provides the first integrated evaluation of DV-AuNPs in a TNBC model encompassing physicochemical characterisation, colloidal stability, differential cellular responses, clonogenic capacity, migration, EMT-associated proteins, and intracellular localisation. Altogether, these findings demonstrate cell-line-dependent biological responses to DV-AuNPs and support their continued investigation as biologically functionalised gold nanoparticles for breast-cancer applications. Further studies are required to define the underlying mechanisms and evaluate activity across additional TNBC models.
Indexed as
Identifiers
42873468What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.