SynthesisSports medicine (Auckland, N.Z.)2026
Effects of Exercise Training on the Metabolic Cost of Walking in Health and Disease: A Systematic Review and Meta-analysis.
Synthesis in Sports medicine (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe metabolic cost of walking (Cw) increases with heathy aging and in neurological conditions. No comprehensive assessment has been performed yet to determine whether chronic exercise training and rehabilitation could improve Cw.
objectiveThe purpose of this study was to determine whether the effects of chronic exercise interventions on Cw differ by type, dose, and intensity in healthy adults and individuals with neurological conditions (multiple sclerosis, Parkinson's disease, and stroke).
designSystematic review and robust variance estimation meta-analysis with meta-regression following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. DATA SOURCES: Systematic search of Medline, Web of Science, and CINAHL databases.
resultsA total of 27 studies with 36 intervention arms and 54 outcomes in 1177 participants, of those 703 healthy adults and 474 patients with multiple sclerosis (1 study), Parkinson's disease (1 study), and stroke (9 studies) were included. Across all types of training (aerobic, resistance, other), chronic physical exercise training improved Cw (g = 0.40, p = 0.001). Improvements were significant in healthy individuals (g = 0.49, p = 0.001) but not in patients with stroke (g = 0.24, p = 0.065). Meta-regression confirmed that population moderated the effects of training on Cw (p = 0.043) after adjusting for exercise training characteristics. In the adjusted meta-regression, higher study-level mean body mass index (BMI) was associated with smaller intervention effects on Cw (β = - 0.20, p = 0.040). Training type, duration, intensity, frequency, and session duration did not significantly moderate the training effects on Cw, although the meta-regression may have been underpowered to detect such associations. Heterogeneity (I
conclusionsThis is the first meta-synthesis examining the effects of diverse forms of exercise training on Cw in different populations. Chronic physical exercise training improves Cw in healthy adults, with smaller effects observed in individuals with stroke. The findings support chronic physical exercise training as an effective strategy for improving walking economy.
Identifiers
42873454What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.