Evidence map›Paper›PMID 42873451›Full record

ArticleGeroScience2026

Plasma biomarkers of neurodegeneration and physical performance in older adults.

Alice C von Alvensleben, Eunjung Kim, Tobias Kurth, Meryl S LeBoff, Amirah K Anderson, Ting Yang, Yi Ran Xu, Beth L Ostaszewski, Dennis J Selkoe, Howard D Sesso and 2 more

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alice C von AlvenslebenInstitute of Public Health, Charité - University Medical Center Berlin, 10117 Berlin, Germany.
Eunjung KimDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Tobias KurthInstitute of Public Health, Charité - University Medical Center Berlin, 10117 Berlin, Germany.
Meryl S LeBoffDivision of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Amirah K AndersonDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Ting YangDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Yi Ran XuDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Beth L OstaszewskiDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Dennis J SelkoeDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Howard D SessoDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
JoAnn E MansonDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Pamela M RistDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. prist@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-3543-045X

Funding

Brigham and Women's Hospital Women's Brain Initiative
6 · The paper itself

Abstract

Physical performance declines with age, but its association with circulating neurodegeneration biomarkers remains unclear. Blood biomarkers including NT1, NfL, oAβ, and pTau217 may reflect early neurodegenerative changes linked to physical performance decline. Evidence linking these biomarkers to physical performance is limited. We analyzed older adults in the COSMOS Clinic substudy with baseline and two-year follow-up assessments of plasma NT1, NfL, and oAβ and a single assessment of pTau217. Physical performance was assessed using walking speed, grip strength, and the Short Physical Performance Battery (SPPB). The primary analysis examined associations between baseline biomarker levels and two-year changes in physical performance. Secondary analyses examined longitudinal associations between two-year changes in biomarkers and concurrent changes in physical performance. Models were adjusted for demographics, cardiovascular risk profile, body mass index, and the baseline value of the physical performance measures, and we considered all biomarkers jointly. We included 506 participants; the mean age was 69.7 years, and 49.3% were women. In the primary analysis, we found no statistically significant associations between baseline NT1, NfL, or oAβ and two-year changes in physical performance. In fully adjusted models, baseline NfL was not associated with 2-year changes in physical performance, with estimates ranging from β = -0.046 (p = 0.69) for SPPB to β = 0.350 (p = 0.48) for grip strength. Similarly, estimates for NT1 ranged from β = -0.097 (p = 0.50) for SPPB to β = 0.267 (p = 0.67) for grip strength, and those for oAβ ranged from β = -0.124 (p = 0.39) for grip strength to β = 0.008 (p = 0.25) for fast walking speed. In the secondary longitudinal analysis, two-year change in NT1 was statistically significantly associated with change in grip strength (β = 1.408, p = 0.01). No other significant associations were observed. Baseline NT1, NfL, or oAβ were not associated with changes in physical performance measures over two years. Changes in NT1 were associated with changes in grip strength. Overall, these biomarkers provided limited information on short-term physical performance decline.

Indexed as

AgeingAlzheimer’s diseaseNeurofilament light chainPhysical performancePlasma biomarkers

Identifiers

PMID42873451

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.