Evidence map›Paper›PMID 42873432›Full record

ArticleJournal of assisted reproduction and genetics2026

Effect of embryo retention on in vitro fertilization outcomes: a retrospective analysis.

Lucia Maresca, Livia Pellegrini, Cecilia Zanini, Luisa Loiudice, Antonio Pellicer, Mauro Cozzolino

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lucia Maresca1. IVIRMA Global Research Alliance, IVI Roma, Rome, Italy.
Livia Pellegrini1. IVIRMA Global Research Alliance, IVI Roma, Rome, Italy.
Cecilia Zanini1. IVIRMA Global Research Alliance, IVI Roma, Rome, Italy.
Luisa Loiudice1. IVIRMA Global Research Alliance, IVI Roma, Rome, Italy.
Antonio Pellicer1. IVIRMA Global Research Alliance, IVI Roma, Rome, Italy.
Mauro CozzolinoDepartment of Reproductive Medicine, 3.IVIRMA Global Research Alliance, IVI Foundation-IIS la Fe, Valencia, Spain. mauro.cozzolino@ivirma.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the incidence of embryo retention (ER) during blastocyst single embryo transfer (SET) cycles and assess its impact on reproductive outcomes in vitro fertilization IVF.

methodsIn this retrospective cohort study, 4593 SET cycles from 3061 patients treated at a single IVF center between October 2021 and July 2024 were analyzed. Cycles were categorized according to the occurrence of ER during embryo transfer (ER group, n = 106; control group, n = 4487). Both fresh and frozen transfers using autologous or donor oocytes were included. The primary outcome was live birth rate (LBR). Secondary outcomes included implantation, biochemical pregnancy, clinical pregnancy, ongoing pregnancy, and miscarriage rates. Logistic regression analyses were performed to evaluate associations between ER and reproductive outcomes.

resultsER occurred in 2.3% of SET cycles. Implantation and early pregnancy outcomes were significantly lower in the ER group compared with controls. After adjustment, ER remained significantly associated with lower implantation (aOR 0.84, 95% CI 0.76-0.92; p < 0.001), biochemical pregnancy (aOR 0.49, 95% CI 0.32-0.75; p < 0.001), and clinical pregnancy rates (aOR 0.53, 95% CI 0.34-0.82; p = 0.004). No statistically significant associations were observed for ongoing pregnancy, live birth, or miscarriage.

conclusionIn this cohort, ER during single blastocyst transfer was associated with lower implantation and early pregnancy rates. These findings should nevertheless be interpreted in light of the potential influence of procedural factors associated with embryo transfer. The association between ER and ongoing pregnancy or live birth remains inconclusive.

Indexed as

BlastocystEmbryo retentionEmbryo transferIVFLive birth

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.