ArticleNeurochemical research2026
IMRCs Alleviate Post-resuscitation Cerebral Injury Possibly by Inhibiting Ferroptosis in a Porcine Model of Cardiac Arrest.
Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cerebral injury following cardiac arrest (CA) is a primary contributor to patients' mortality and poor neurological outcome. However, there are currently no definitive and effective therapeutic approaches. Emerging evidence has indicated that mesenchymal stem cell (MSC) pretreatment exerted protective effects against cardiac and cerebral injuries in the porcine model of CA. However, given the unpredictable nature of CA, we administered immunity-and-matrix-regulatory cells (IMRCs) derived from human embryonic stem cells (hESCs) following CA to investigate whether IMRCs could alleviate cerebral injury following CA in swine. In vivo, a porcine CA model was established using male domestic white swine. In vitro, CA-induced injury was simulated by subjecting HT22 cells and primary cultures of hippocampal neurons to hypoxia/reoxygenation (H/R). SAT1 overexpression was achieved in HT22 cells via lentiviral transduction and in primary cultures of hippocampal neurons via adeno‑associated virus (AAV) transduction. Following IMRC administration, neurological function, cerebral injury, cell viability, lactate dehydrogenase (LDH) release, and ferroptosis-related indicators were systematically evaluated using a series of experimental assays. IMRC administration significantly decreased ferroptosis-related ferrous iron (Fe
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