Evidence map›Paper›PMID 42873391›Full record

ReviewNano convergence2026

Safe and sustainable by design (SSbD) for nanotechnology: scientific foundations, global policy perspectives, and industrial practice.

Zayakhuu Gerelkhuu, Angela Serra, Seung-Geun Park, Ishita Virmani, Aline Maria Zigiotto de Medeiros, Ariadna Acedo-Terrades, Fotini Nikiforou, Achilleas Karakoltzidis, Seong-Kwan Kim, Hyeonsoo Eom and 28 more

Abstract readReview
In one paragraph

Review in Nano convergence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Zayakhuu GerelkhuuResearch Institute for Convergence of Basic Science, Hanyang University, Seoul, 04763, Republic of Korea. zayakhuu19@hanyang.ac.kr.
Angela SerraFinnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, 33100, Tampere, Finland.
Seung-Geun ParkDepartment of Chemistry, Hanyang University, Seoul, 04763, Republic of Korea.
Ishita VirmaniInstitute of Medical Biochemistry, Medical University Innsbruck, 6020, Innsbruck, Austria.
Aline Maria Zigiotto de MedeirosBrazilian Center for Research in Energy and Materials (CNPEM), Brazilian Nanotechnology National Laboratory (LNNano), Campinas, São Paulo, Brazil.
Ariadna Acedo-TerradesSwiss Federal Laboratories for Materials Science and Technology, Laboratory for Nanomaterials in Health, Empa, Lerchenfeldstrasse 5, 9014, St. Gallen, Switzerland.
Fotini NikiforouEnvironmental Engineering Laboratory, Department of Chemical Engineering, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece.
Achilleas KarakoltzidisEnvironmental Engineering Laboratory, Department of Chemical Engineering, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece.
Seong-Kwan KimDepartment of Research and Development, Safety Core Lab. Co. Ltd, Seoul, 04309, Republic of Korea.
Hyeonsoo EomDepartment of Research and Development, Safety Core Lab. Co. Ltd, Seoul, 04309, Republic of Korea.
Martin HimlyDepartment of Biosciences & Medical Biology, Paris Lodron University Salzburg, Hellbrunnerstrasse 34, 5020, Salzburg, Austria.
Dimitris G MintisNanoinformatics Department, NovaMechanics Ltd, Nicosia, Cyprus.
Vasileios MinadakisSchool of Chemical Engineering, National Technical University of Athens, 15772, Athens, Greece.
Dimitra-Danai VarsouSchool of Chemical Engineering, National Technical University of Athens, 15772, Athens, Greece.
Spyros KarakitsiosEnvironmental Engineering Laboratory, Department of Chemical Engineering, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece.
Dimosthenis A SarigiannisEnvironmental Engineering Laboratory, Department of Chemical Engineering, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece.
Giusy Del GiudiceFinnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, 33100, Tampere, Finland.
Marcella Torres MaiaFinnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, 33100, Tampere, Finland.
Michele FratelloFinnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, 33100, Tampere, Finland.
Anastasios G PapadiamantisNanoinformatics Department, NovaMechanics Ltd, Nicosia, Cyprus.
Panagiotis IsigonisLuxembourg Institute of Science and Technology (LIST), 4362, Esch-sur- Alzette, Luxembourg.
Anna PohlAcumenIST SRL, Rue Fétis 19, Etterbeek, 1040, Brussels, Belgium.
Sang Hee LeeEnvironmental Risk Research Division, Environmental Health Research Department, National Institute of Environmental Research, Incheon, 22689, Republic of Korea.
Byung-Tae LeeEnvironmental Analysis Center, Gwangju Institute of Science and Technology, Jeonnam-Gwangju, 61005, Republic of Korea.
Yang-Won SuhSustainable Development Research Group, Korea Environment Institute, Sejong, 30147, Republic of Korea.
Candida LorussoDepartment of Science and Technological Innovation, Università del Piemonte Orientale, 15121, Alessandria, Italy.
Francesco DonderoDepartment of Science and Technological Innovation, Università del Piemonte Orientale, 15121, Alessandria, Italy.
Steffi FriedrichsAcumenIST SRL, Rue Fétis 19, Etterbeek, 1040, Brussels, Belgium.
Antreas AfantitisNanoinformatics Department, NovaMechanics Ltd, Nicosia, Cyprus.
Haralambos SarimveisSchool of Chemical Engineering, National Technical University of Athens, 15772, Athens, Greece.
Eva-Kathrin SchillingerInnovative Advanced Materials Inititiave, Rue Belliard 40, 1040, Brussels, Belgium.
Peter WickSwiss Federal Laboratories for Materials Science and Technology, Laboratory for Nanomaterials in Health, Empa, Lerchenfeldstrasse 5, 9014, St. Gallen, Switzerland.
Diego Stéfani Teodoro MartinezBrazilian Center for Research in Energy and Materials (CNPEM), Brazilian Nanotechnology National Laboratory (LNNano), Campinas, São Paulo, Brazil.
Iseult LynchEntelos Institute, Larnaca, Cyprus.
Thomas E ExnerSeven Past Nine d.o.o, 1380, Cerknica, Slovenia.
Tommaso SerchiLuxembourg Institute of Science and Technology (LIST), 4362, Esch-sur- Alzette, Luxembourg.
Tae Hyun YoonResearch Institute for Convergence of Basic Science, Hanyang University, Seoul, 04763, Republic of Korea.
Dario GrecoFinnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University, 33100, Tampere, Finland. dario.greco@tuni.fi.

Funding

Hanyang University HY-202100000670025HORIZON EUROPE Framework Programme 101092686HORIZON EUROPE Framework Programme 101137613HORIZON EUROPE Framework Programme 101137742HORIZON EUROPE Framework Programme 101137809Korea-EU Joint Research Support Program RS-2025-25458852National Council for Scientific and Technological Development 443735/2023-9National Research Foundation of Korea, Nano Material Technology Development Program RS-2024-00452934Sao Paulo Research Foundation 2023/13081-0 and 2024/00989-7
6 · The paper itself

Abstract

Safe and Sustainable by Design (SSbD) is emerging as a transformative framework for integrating safety and sustainability with functionality in nanotechnology. This review provides a unified perspective on SSbD, bridging its scientific foundations, global policy developments, and industrial implementation. We highlight how advances in mechanistic understanding of nanomaterial-biological interactions enable earlier and more predictive safety assessment, supporting informed material design. At the policy level, evolving regulatory and governance approaches across regions are shaping the integration of sustainability and safety requirements. From an industrial perspective, SSbD is driving innovation in material substitution, process optimization, and lifecycle-oriented design. Despite this progress, challenges remain in standardization, data integration, and alignment between regulatory frameworks and industrial practice. This work positions SSbD as a central paradigm for enabling responsible innovation and accelerating the transition toward safer and more sustainable nanotechnologies.

Indexed as

Industrial practiceLife cycle assessmentNanomaterialsNanosafetyRegulatory policyRisk assessmentSafe and sustainable by designSustainability

Identifiers

PMID42873391
PMCPMC13669271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.