Evidence map›Paper›PMID 42873248›Full record

ArticleEuropean child & adolescent psychiatry2026

From childhood to adulthood: an attempt to model long-term outcomes of ADHD using machine learning.

Noa van der Plas, Frank Bennis, Barbara Franke, Catharina Hartman, Pieter Hoekstra, Anna Nijmeijers, Lennart Oblong, Nanda Rommelse, Emma Sprooten, Marjolein Luman and 2 more

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Article in European child & adolescent psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Noa van der PlasVrije Universiteit Amsterdam, Amsterdam, Netherlands. n.e.vander.plas@vu.nl.ORCID https://orcid.org/0009-0003-8040-6691
Frank BennisEmma Kinderziekenhuis, Amsterdam, Netherlands.
Barbara FrankeRadboud University Nijmegen, Nijmegen, Netherlands.
Catharina HartmanUniversity of Groningen, Groningen, Netherlands.
Pieter HoekstraUniversity of Groningen, Groningen, Netherlands.
Anna NijmeijersVrije Universiteit Amsterdam, Amsterdam, Netherlands.
Lennart OblongRadboud University Nijmegen, Nijmegen, Netherlands.
Nanda RommelseUtrecht University, Utrecht, Netherlands.
Emma SprootenRadboud University Nijmegen, Nijmegen, Netherlands.
Marjolein LumanVrije Universiteit Amsterdam, Amsterdam, Netherlands.
Jaap OosterlaanVrije Universiteit Amsterdam, Amsterdam, Netherlands.
Siri NoordermeerVrije Universiteit Amsterdam, Amsterdam, Netherlands.

Funding

Stichting tot Steun Vereniging tot Christelijke Verzorging van Geestes- en Zenuwzieken 279ZonMw 55500302
6 · The paper itself

Abstract

backgroundChildhood-onset attention-deficit/hyperactivity disorder (ADHD) persists in 28% to 58% of individuals, and is associated with adverse long-term outcomes, like additional psychiatric diagnoses and lower educational attainment. Knowing early life predictors for adverse long-term outcomes might help develop preventive measures, but too few have been identified using conventional statistical models. The current study investigated the potential of machine learning in identifying predictors for ADHD persistence and long-term functioning of adults with childhood-onset ADHD.

methodA total of 133 adults (M

resultsPerformance of all models for ADHD persistence and functioning (quality of life) was low. Best performing models included the logistic regression model with resampling for ADHD persistence (AUC's

conclusionsFindings highlight the complexity of predicting long-term outcomes of ADHD. Model improvement is crucial before models can inform clinical practice, e.g., by increasing sample size and investigating additional predictors.

Indexed as

ADHDLong-term outcomesMachine learningPredicting

Identifiers

PMID42873248

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.