Evidence map›Paper›PMID 42873229›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026

Investigation of reported small molecule P2Y6 receptor antagonists.

Chianna Dane, André D J McKenzie, Andrew P Montgomery, Jonathan Du, Eryn L Werry, Michael Kassiou

Abstract read
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In one paragraph

Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chianna Dane *School of Chemistry, Faculty of Science, University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0009-0001-3730-9453
André D J McKenzie *School of Chemistry, Faculty of Science, University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0002-8012-4745
Andrew P MontgomerySchool of Chemistry, Faculty of Science, University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0002-1819-3619
Jonathan DuSydney Pharmacy School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0002-7750-4413
Eryn L WerrySchool of Chemistry, Faculty of Science, University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0002-6224-1286
Michael KassiouSchool of Chemistry, Faculty of Science, University of Sydney, Sydney, NSW, 2006, Australia. michael.kassiou@sydney.edu.au.ORCID http://orcid.org/0000-0002-6655-0529

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interest in the P2Y6 receptor (P2Y6R) has increased substantially over the past decade, driven by evidence that pharmacological inhibition is beneficial in neurodegenerative disease models, inflammatory pathologies, and cancer. However, therapeutic targeting of the P2Y6R has remained a challenge due to a lack of available drug-like molecules. In 2023 and 2024, benzimidazole and quinoline chemotypes respectively, were reported as potent P2Y6R antagonists with pharmacological relevance in an inflammatory bowel disease model. In the present study positive and negative controls from each chemotype were selected, and their functional activity at hP2Y6R was assessed prior to chemical diversification. Contrary to the published literature, none of the antagonists exhibited functional activity in our Ca

Indexed as

BenzimidazolesPurinergic P2 Receptor AntagonistsQuinolinesReceptors, Purinergic P2Small Molecule LibrariesAnimalsHumansStructure-Activity RelationshipBenzimidazolesPurinergic P2 Receptor Antagonistspurinoceptor P2Y6QuinolinesReceptors, Purinergic P2Small Molecule LibrariesAntagonistGPCRP2Y6 receptorSmall moleculeValidation

Identifiers

PMID42873229
PMCPMC13669135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.