Evidence map›Paper›PMID 42873093›Full record

SynthesisClinical transplantation2026

Risk of Donor-Derived Infections From Organ Donors Colonized or Infected With Multidrug-Resistant Gram-Negative Bacteria: A Systematic Review and Meta-Analysis.

Themistoklis Paraskevas, Christodoulos Chatzigrigoriadis, Ioannis D Kostakis, Nikolaos Karydis, Marios Papasotiriou, Theodoros Ntrinias, Ioannis Maroulis, Markos Marangos, Evangelos Papachristou, Paolo Antonio Grossi and 1 more

Abstract readSystematic ReviewMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Themistoklis Paraskevas *Department of Nephrology and Kidney Transplantation, Faculty of Medicine, University General Hospital of Patras, University of Patras, Patras, Greece.
Christodoulos Chatzigrigoriadis *Department of Internal Medicine, Division of Infectious Diseases, Faculty of Medicine, University General Hospital of Patras, University of Patras, Patras, Greece.
Ioannis D KostakisDepartment of Surgery, Faculty of Medicine, University General Hospital of Patras, University of Patras, Patras, Greece.
Nikolaos KarydisDepartment of Surgery, Faculty of Medicine, University General Hospital of Patras, University of Patras, Patras, Greece.
Marios PapasotiriouDepartment of Nephrology and Kidney Transplantation, Faculty of Medicine, University General Hospital of Patras, University of Patras, Patras, Greece.
Theodoros NtriniasDepartment of Nephrology and Kidney Transplantation, Faculty of Medicine, University General Hospital of Patras, University of Patras, Patras, Greece.
Ioannis MaroulisDepartment of Surgery, Faculty of Medicine, University General Hospital of Patras, University of Patras, Patras, Greece.
Markos MarangosDepartment of Internal Medicine, Division of Infectious Diseases, Faculty of Medicine, University General Hospital of Patras, University of Patras, Patras, Greece.
Evangelos PapachristouDepartment of Nephrology and Kidney Transplantation, Faculty of Medicine, University General Hospital of Patras, University of Patras, Patras, Greece.
Paolo Antonio GrossiInfectious and Tropical Diseases Unit, Department of Medicine and Surgery, University of Insubria, ASST Sette Laghi, Varese, Italy.
Stelios F AssimakopoulosDepartment of Internal Medicine, Division of Infectious Diseases, Faculty of Medicine, University General Hospital of Patras, University of Patras, Patras, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe presence of multidrug-resistant Gram-negative (MDR-GN) organisms in solid organ transplantation (SOT) donors raises concerns regarding transplant safety.

methodsWe searched PubMed and Scopus (2010-2025) for observational studies reporting donor-derived infections (DDI) among SOT recipients from donors with MDR-GN colonization or infection. A single-arm meta-analysis was performed. Subgroup analyses examined donor risk categories (high-risk, low-risk), organ types, pathogen groups, and donor culture sites. 90-day mortality was estimated for recipients at risk of donor-to-recipient transmission based on presence of MDR-GN DDI.

resultsTwelve cohort studies with 457 recipients were included. The pooled attack rate of MDR-GN DDI was 29% (95%CI: 11%-49%). DDI occurred in 40% (95%CI: 20%-62%) of high-risk transplantations but was absent in low-risk scenarios (0%, 95%CI: 0%-1%). Transmission was associated with graft-relevant exposure, including preservation fluid positivity (58%, 95%CI: 23%-89%) and organ-specific cultures. 90-day mortality among recipients corresponding to donors with carriage of MDR-GN pathogens was 14% (95%CI: 6%-30%). Higher 90-day mortality was observed among recipients with evidence of MDR-GN DDI (49%, 95%CI: 12%-87%).

conclusionsAlthough transmission from MDR-GN donors seems to increase the mortality of the recipients, it is highly context-dependent and primarily driven by graft-related anatomical exposure rather than MDR status alone.

Indexed as

Drug Resistance, Multiple, BacterialGram-Negative BacteriaGram-Negative Bacterial InfectionsOrgan TransplantationTissue DonorsHumansPrognosisRisk Factorsdonor‐derived infectionsmultidrug‐resistant gram‐negative bacteriasolid organ transplantation

Identifiers

PMID42873093
PMCPMC13665600

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.