Evidence map›Paper›PMID 42872890›Full record

ArticleEuropean journal of neurology2026

Migraine in Older Adults: Age-Related Clinical Features From the Italian RICe Registry.

Giulia Paparella, Luigi Francesco Iannone, Giulia Paparella, Grazia Sances, Roberto De Icco, Gloria Vaghi, Cristina Tassorelli, Andrea Burgalassi, Francesco De Cesaris, Alberto Chiarugi and 23 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Giulia PaparellaNeurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.ORCID https://orcid.org/0000-0002-7760-9442
Luigi Francesco IannoneDepartment of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy.ORCID https://orcid.org/0000-0003-3598-0195
Giulia PaparellaNeurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Grazia SancesHeadache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy.ORCID https://orcid.org/0000-0001-8257-2886
Roberto De IccoHeadache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy.ORCID https://orcid.org/0000-0001-9415-4948
Gloria VaghiHeadache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy.ORCID https://orcid.org/0000-0003-0117-7126
Cristina TassorelliHeadache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy.ORCID https://orcid.org/0000-0003-1513-2113
Andrea BurgalassiHeadache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy.ORCID https://orcid.org/0009-0001-7028-7735
Francesco De CesarisHeadache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy.
Alberto ChiarugiHeadache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy.
Francesca GabrieleDepartment of Biotechnological and Applied Clinical Sciences, University of L'aquila, L'Aquila, Italy.ORCID https://orcid.org/0009-0006-0393-2956
Raffaele OrnelloDepartment of Biotechnological and Applied Clinical Sciences, University of L'aquila, L'Aquila, Italy.ORCID https://orcid.org/0000-0001-9501-4031
Simona SaccoDepartment of Biotechnological and Applied Clinical Sciences, University of L'aquila, L'Aquila, Italy.ORCID https://orcid.org/0000-0003-0651-1939
Maria Pia PrudenzanoNeurology Unit "L. Amaducci"-Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Martino GentileNeurology Unit "L. Amaducci"-Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Damiano PaolicelliNeurology Unit "L. Amaducci"-Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Giorgia Dalla VoltaU.O. Neurologia, Istituto Clinico Città di Brescia, Gruppo San Donato, Brescia, Italy.
Marco BolchiniU.O. Neurologia, Istituto Clinico Città di Brescia, Gruppo San Donato, Brescia, Italy.ORCID https://orcid.org/0000-0002-5161-5545
Innocenzo RaineroDepartment of Neuroscience, Headache Center, University of Torino, Turin, Italy.
Elisa RubinoDepartment of Neuroscience, Headache Center, University of Torino, Turin, Italy.
Maria AlbaneseIRCCS Neuromed, Pozzilli, Italy.ORCID https://orcid.org/0000-0002-5113-2017
Fabrizio VernieriHeadache and Neurosonology Unit, Fondazione Policlinico Campus Bio-Medico, Rome, Italy.ORCID https://orcid.org/0000-0002-9594-9336
Gianluca CoppolaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.ORCID https://orcid.org/0000-0002-8510-6925
Gianluca AvinoSOC Neurologia, Ospedale Santo Stefano, USL Toscana Centro, Prato, Italy.ORCID https://orcid.org/0000-0002-2878-560X
Edoardo MampresoNeurology-Euganea, Health Unit, Headache Centre, Padua, Italy.
Delfina FerrandiS.C. Neurologia, Azienda Ospedaliera Universitaria Santi Antonio e Biagio, Alessandria, Italy.
Marta AltieriDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Stefania BattistiniDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.ORCID https://orcid.org/0000-0003-2887-7624
Antonio GranatoHeadache Center, Neurology Clinic, University Hospital of Trieste, University of Trieste, Trieste, Italy.
Simona GuerzoniDigital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology, Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy.ORCID https://orcid.org/0000-0001-9589-2782
Antonio RussoHeadache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Marina de TommasoNeurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.ORCID https://orcid.org/0000-0001-6567-5373
RICe Study Group

Funding

Ministero della Salute Current Research 2026
6 · The paper itself

Abstract

backgroundPrimary headaches, particularly migraine, are prevalent disorders insufficiently characterized in older adults. This multicentre study evaluated headache diagnoses, focusing on migraine, across age groups in headache centers participating in the Italian Registry for Headache Disorders (RICe).

methodsUsing a post hoc design, we evaluated 3477 patients enrolled at 30 headache centers (2019-2025). Patients were stratified into young adults (18-30 years), adults (31-45 years), middle-aged (46-59 years), and elderly individuals (≥ 60 years). Demographic and clinical migraine characteristics were collected. Group differences were assessed using χ

resultsOf 3477 patients, 644 (18.5%) were elderly, 1285 (36.9%) middle-aged, 990 (28.5%) adults, and 558 (16.1%) young adults. Among migraine patients (n = 3013, 86.7%), diagnoses differed across age groups (χ

conclusionsOlder adults attending headache centers more frequently presented CM, with higher attack frequency, lower pain severity, greater medication overuse, and distinct triggers, supporting tailored diagnostic and therapeutic strategies.

Indexed as

Migraine DisordersRegistriesAdolescentAdultAgedAge FactorsFemaleHumansItalyMaleMiddle AgedYoung Adultagingelderlyheadachemigraineregistry

Identifiers

PMID42872890
PMCPMC13664672

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.