ArticleCell proliferation2026
MD-1 Deficiency Mitigates Atherosclerosis by Inhibiting NLRP3 Inflammasome Activation via cGAS-STING Dependent Pathway in Macrophages.
Article in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
MD-1 plays significant roles in various pathological processes closely associated with cardiovascular diseases through its functions in different cell types. However, the critical effects and molecular mechanisms mediated by MD-1 in macrophages involved in the development of atherosclerosis remain elusive. In this study, we observed that the expression of MD-1 was upregulated in atherosclerotic plaques derived from human carotid arteries, as analysed through the Gene Expression Omnibus database. Additionally, MD-1 expression was elevated in the aortas of hyperlipidemic ApoE-deficient mice and in oxidised low-density lipoprotein-stimulated bone marrow-derived macrophages, as demonstrated by RT-PCR and western blot analyses. Furthermore, MD-1 expression exhibited strong co-localisation with macrophages, as confirmed by double immunofluorescence staining. Notably, MD-1
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