ArticleSoft matter2026
Rheology and programmable gelation of DNA tadpoles.
Article in Soft matter, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
DNA origami is a powerful method to achieve nanoscale folded structures. DNA origami is typically employed to create precisely and tightly folded objects often in small quantities and studied at single molecule scale. Here, we use the DNA origami method to design and fold polymers with complex topologies, and study their rheology and viscoelastic properties in dense conditions. First, we designed and purified topologically distinct DNA nanostructures - linear, circular, and "tadpole" polymers - to evaluate how polymer architecture influences entanglement and rheology. Despite their distinct topologies, we observe that all constructs obeyed universal rheological scalings, likely due to their short length. However, upon thermal annealing in the bulk, the DNA polymers displayed significantly different behaviours. Our results suggest that DNA polymers could be used to engineer thermoresponsive behaviours in complex fluids by introducing reversible and topology-dependent crosslinking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.