ArticleJournal of biomedical optics2026
Comparison of volumetric dynamic optical coherence tomography with biological methods for evaluation of radiation effects in prostate tumor spheroids.
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Significance: Three-dimensional (3D) tumor spheroids are more physiologically representative of Aim: Non-invasive volumetric imaging with dynamic optical coherence tomography (dOCT) enables cellular activity to be visualized with spatial resolution within 3D tumor spheroids. Cellular activity observed via dOCT in irradiated prostate tumor spheroids was quantified for comparison with conventional biological techniques. Approach: A Varian TrueBeam linear accelerator was used to irradiate spheroid and monolayer cultures with a 6-MV beam. Cellular activity was estimated from dOCT images generated via frequency banding and compared with clonogenic assay, proliferation assay, fluorescence microscopy, and 3D cell simulation. Results: Prostate cancer cells cultured as spheroids demonstrated improved radio-resistance via clonogenic assay compared with monolayer culture. The dOCT method demonstrated quantitative and qualitative agreement with the proliferation assay and fluorescence microscopy, respectively. Conclusions: A longer duration of repeated dOCT measurement in tumor spheroids following radiation treatment could offer a non-invasive alternative to the clonogenic assay.
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