Evidence map›Paper›PMID 42872211›Full record

ArticleRespiratory medicine case reports2026

Early-onset severe voriconazole-induced liver injury with progressive cholestasis in pulmonary aspergillosis: A case report.

Phan Thanh Thuy, Hoang Thanh Tam, Nguyen Thi Thu Ha, Dang Minh Duc, Nguyen Hoang Anh, Nguyen Thi Thanh Huyen, Nguyen Trung Nguyen, Phan Thu Phuong, Vu Van Giap

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PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Phan Thanh ThuyHanoi Medical University, Hanoi, Viet Nam.
Hoang Thanh TamHanoi Medical University, Hanoi, Viet Nam.
Nguyen Thi Thu HaDepartment of Pharmacy, Bach Mai Hospital, Hanoi, Viet Nam.
Dang Minh DucDepartment of Pharmacy, Bach Mai Hospital, Hanoi, Viet Nam.
Nguyen Hoang AnhDepartment of Pharmacy, Bach Mai Hospital, Hanoi, Viet Nam.
Nguyen Thi Thanh HuyenInstitute of Respiratory Medicine, Bach Mai Hospital, Hanoi, Viet Nam.
Nguyen Trung NguyenPoison Control Center, Bach Mai Hospital, Hanoi, Viet Nam.
Phan Thu PhuongHanoi Medical University, Hanoi, Viet Nam.
Vu Van GiapHanoi Medical University, Hanoi, Viet Nam.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Voriconazole is the recommended first-line treatment for invasive pulmonary Case presentation: A 76-year-old Asian man with chronic obstructive pulmonary disease, type 2 diabetes mellitus, hypertension, polycythemia, and glucocorticoid-induced adrenal insufficiency was admitted with an infective exacerbation of COPD. Sputum culture identified Conclusions: This case highlights early-onset severe voriconazole-induced liver injury with subsequent progressive cholestasis in an older patient with multiple comorbidities. Liver injury may continue to worsen despite prompt drug discontinuation. Careful monitoring of liver function during the first 1-2 weeks of voriconazole therapy and therapeutic drug monitoring, when available, may facilitate earlier recognition of hepatotoxicity and improve patient safety.

Indexed as

Case reportCholestasisChronic obstructive pulmonary diseaseDrug-induced liver injuryHepatotoxicityTherapeutic drug monitoringTherapeutic plasma exchangeVoriconazole

Identifiers

PMID42872211
PMCPMC13660653

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