ReviewNeuropsychiatric disease and treatment2026
Advances in the Antidepressant Effects of Electroacupuncture Through Regulation of Microglia-Mediated BDNF Signaling and Hippocampal Neurogenesis.
Review in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To summarize the regulatory network linking microglia, brain-derived neurotrophic factor (BDNF) signaling, and hippocampal neurogenesis, and to clarify the potential antidepressant mechanisms of electroacupuncture. Methods: We systematically reviewed and integrated recent findings from preclinical and clinical studies regarding microglial activation, BDNF/tropomyosin receptor kinase B (TrkB) signaling, hippocampal neurogenesis, and electroacupuncture intervention in depressive disorders, retrieved from PubMed, Web of Science, and CNKI databases up to June 2026. Results: Depression is closely associated with neuroinflammation, impaired neuroplasticity, and disrupted hippocampal neurogenesis. Aberrant microglial activation may inhibit hippocampal neurogenesis by releasing pro-inflammatory cytokines, excessively engulfing synapses, and disturbing the neural microenvironment. These pathological changes interact with dysregulated BDNF/TrkB signaling and jointly contribute to depressive phenotypes. Electroacupuncture may exert antidepressant effects by modulating microglial phenotypic transformation, suppressing pro-inflammatory mediator release, and upregulating BDNF/TrkB signaling and its downstream pathways. Conclusion: Electroacupuncture may improve depression through coordinated regulation of microglia-mediated neuroinflammation and BDNF-related neuroplasticity. This mechanism provides a scientific basis for further mechanistic research and clinical application of acupuncture in depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.