Evidence map›Paper›PMID 42872183›Full record

ReviewMedComm2026

Carbon Quantum Dots: From Mechanisms to Biomedical Applications.

Bingxin Fan, Nianqiang Jin, Nuo Jin, Jiayu Shen, Xinliang Duan, Sichen Han, Yao Yuan, Zilin Wang

Abstract readReview
In one paragraph

Review in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bingxin FanDepartment of Oral and Maxillofacial Surgery Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology Jilin University Changchun China.
Nianqiang JinSchool of Stomatology Stomatological Hospital Southern Medical University Guangzhou People's Republic of China.ORCID https://orcid.org/0000-0001-8307-9313
Nuo JinSchool of Stomatology Stomatological Hospital Southern Medical University Guangzhou People's Republic of China.
Jiayu ShenDepartment of Oral and Maxillofacial Surgery Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology Jilin University Changchun China.
Xinliang DuanDepartment of Oral and Maxillofacial Surgery Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology Jilin University Changchun China.
Sichen HanDepartment of Oral and Maxillofacial Surgery Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology Jilin University Changchun China.
Yao YuanDepartment of Oral and Maxillofacial Surgery Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology Jilin University Changchun China.
Zilin WangDepartment of Oral and Maxillofacial Surgery Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology Jilin University Changchun China.ORCID https://orcid.org/0000-0002-9598-3331

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbon quantum dots (CQDs) have emerged as promising nanomaterials for biomedical applications, including bioimaging, drug delivery, biosensing, and tissue regeneration, owing to their favorable biocompatibility, tunable physicochemical properties, and diverse biological activities. Despite accumulating evidence of their regenerative potential, the mechanisms by which CQDs regulate complex tissue regeneration remain insufficiently integrated. In this Review, we synthesize recent advances in the biomedical applications of CQDs, with particular emphasis on material selection for specific disease contexts and their direct and indirect regulatory roles in tissue regeneration. We examine how CQDs modulate cellular functions, angiogenesis, stem cell differentiation, the immune microenvironment, and redox homeostasis through molecular pathways, and how their physicochemical properties shape these biological effects and regenerative outcomes. We further discuss emerging strategies for functional optimization, including multifunctional and stimuli-responsive CQD systems. Finally, we critically assess key translational barriers, including structural characterization, biological evaluation, safety assessment, material standardization, and manufacturing consistency. By linking CQDs' properties to molecular mechanisms and regenerative outcomes, this Review provides a conceptual framework for the rational design of CQDs and the development of more effective regenerative therapies.

Indexed as

carbon quantum dotsprecision therapyregulatory mechanismstissue regeneration

Identifiers

PMID42872183
PMCPMC13660723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.