High Rate of Adverse Events in Patients Receiving Oral Antimicrobials Under a COpAT Monitoring Protocol.

Ciara Sawey, Colleen Burgoyne, Angelina Winbush, Brandon W Qualls, Sonal Munsiff, Alexandra Yamshchikov

Abstract read

In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ciara SaweyDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California, USA.ORCID https://orcid.org/0009-0002-7323-330X

Colleen BurgoyneDivision of Infectious Diseases, University of Rochester, Rochester, New York, USA.ORCID https://orcid.org/0000-0002-6916-3903

Angelina WinbushDepartment of Medicine, University of Rochester, Rochester, New York, USA.ORCID https://orcid.org/0009-0004-3719-116X

Brandon W QuallsClinical Nursing Research Center, University of Rochester Medicine, Rochester, New York, USA.ORCID https://orcid.org/0000-0002-3407-2593

Sonal MunsiffDivision of Infectious Diseases, University of Rochester, Rochester, New York, USA.ORCID https://orcid.org/0000-0002-7493-9163

Alexandra YamshchikovDivision of Infectious Diseases, University of Rochester, Rochester, New York, USA.ORCID https://orcid.org/0009-0002-2558-1027

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted a retrospective review to characterize adverse events in patients receiving oral linezolid, trimethoprim-sulfamethoxazole, voriconazole, and itraconazole monitored under an outpatient parenteral antimicrobial therapy program. Among 118 patients, 61% incurred at least 1 adverse event during treatment, highlighting the need for evidence-based monitoring protocols for complex outpatient antimicrobial therapy.

Indexed as

adverse drug eventscomplex oral antimicrobialsCOpATdrug monitoringphysician guidelines

Identifiers

PMID42872180

DOI10.1093/ofid/ofag590

PMCPMC13660702

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.