ArticleACS pharmacology & translational science2026
Protective Effects of the Phytocystatin CaneCPI‑5 on Periodontal Ligament Cell Osteogenic Activity and Alveolar Bone Loss under Inflammatory Challenge.
Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Periodontal disease is characterized by a chronic inflammatory environment that compromises the regenerative capacity of periodontal tissues, particularly by impairing the osteogenic potential of periodontal ligament cells. Phytocystatins have emerged as bioactive molecules with potential regenerative and immunomodulatory properties; however, their effects on periodontal tissues under inflammatory conditions remain unexplored. In this study, we investigated the effects of CaneCPI-5 on the osteogenic behavior of human periodontal ligament cells (hPDLCs) under basal and inflammatory conditions in vitro, as well as its impact on alveolar bone preservation and periodontal tissue responses in a murine model of experimental periodontitis. In vitro, CaneCPI-5 promoted the expression of osteogenic markers and supported mineralized matrix formation under basal conditions. Notably, CaneCPI-5 preserved osteogenic gene expression and mineral deposition in hPDLCs exposed to
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