Evidence map›Paper›PMID 42872129›Full record

ArticlePulmonary circulation2026

Antithrombotic Therapy Use in Children With Pulmonary Hypertension.

Meredith J O'Neil, Lynn A Sleeper, Nidhy P Varghese, Paul J Critser, Eric D Austin, Catherine M Avitabile, Angela Bates, Erika B Rosenzweig, Carly E Byrd, Patrick D Evers and 14 more

Abstract read
In one paragraph

Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Meredith J O'NeilThe Heart Institute, Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA.ORCID https://orcid.org/0000-0003-3948-5933
Lynn A SleeperDepartment of Cardiology Boston Children's Hospital Boston Massachusetts USA.ORCID https://orcid.org/0000-0002-8055-768X
Nidhy P VargheseDepartment of Pediatrics, Division of Pulmonology Baylor College of Medicine and Texas Children's Hospital Houston Texas USA.ORCID https://orcid.org/0000-0003-4422-3065
Paul J CritserThe Heart Institute, Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA.ORCID https://orcid.org/0000-0001-8634-1399
Eric D AustinDepartment of Pediatrics, Division of Allergy Immunology and Pulmonary Medicine, Vanderbilt Children's Hospital Nashville Tennessee USA.ORCID https://orcid.org/0000-0002-1709-9022
Catherine M AvitabileDepartment of Pediatrics University of Pennsylvania Perelman School of Medicine; Division of Cardiology, Children's Hospital of Philadelphia Philadelphia Pennsylvania USA.ORCID https://orcid.org/0000-0002-2354-5447
Angela BatesDivision of Pediatric Critical Care, Department of Pediatrics University of Alberta Edmonton Alberta Canada.
Erika B RosenzweigDepartments of Pediatrics Maria Fareri Children's Hospital of Westchester Medical Center Health Network and New York Medical College Valhalla New York USA.ORCID https://orcid.org/0000-0003-4849-214X
Carly E ByrdDepartment of Pediatrics Johns Hopkins University School of Medicine Baltimore Maryland USA.ORCID https://orcid.org/0000-0002-5504-5471
Patrick D EversDivision of Pediatric Cardiology, Department of Pediatrics Oregon Health and Science University Portland Oregon USA.ORCID https://orcid.org/0000-0002-9299-1926
Stephanie S HandlerDepartment of Pediatrics (Cardiology) Medical College of Wisconsin Milwaukee Wisconsin USA.
Rachel K HopperDepartment of Pediatrics (Cardiology) Stanford University School of Medicine Palo Alto California USA.ORCID https://orcid.org/0000-0002-7483-2825
Emma O JacksonHeart Center, Seattle Children's Hospital Seattle Washington USA.ORCID https://orcid.org/0009-0005-3343-7502
Roberta L KellerDepartment of Pediatrics, Division of Neonatology University of California San Francisco CA San Francisco California USA.ORCID https://orcid.org/0000-0003-0743-8470
Usha S KrishnanDepartment of Pediatrics Columbia University Irving Medical Center, Children's Hospital of New York Presbyterian New York City New York USA.ORCID https://orcid.org/0000-0002-5733-6096
Minmin LuDepartment of Cardiology Boston Children's Hospital Boston Massachusetts USA.
Jessica MacleanDepartment of Pediatrics, Section of Cardiology University of Colorado School of Medicine Aurora Colorado USA.
Raysa Morales-DemoriDepartment of Pediatrics, Section of Critical Care Baylor College of Medicine Houston Texas USA.ORCID https://orcid.org/0000-0002-7602-7512
Mary P MullenDepartment of Cardiology Boston Children's Hospital Boston Massachusetts USA.ORCID https://orcid.org/0000-0002-0291-9630
Meredith RikerHeart Center, Seattle Children's Hospital Seattle Washington USA.ORCID https://orcid.org/0009-0000-0091-2892
Rachel T SullivanDepartment of Pediatrics, Division of Cardiology Monroe Carrell Jr. Children's Hospital at Vanderbilt Nashville Tennessee USA.ORCID https://orcid.org/0000-0003-4580-9965
Delphine YungDepartment of Pediatrics, Division of Cardiology University of Washington School of Medicine Seattle Washington USA.ORCID https://orcid.org/0000-0002-4571-4977
Benjamin S FrankDepartment of Pediatrics, Section of Cardiology University of Colorado School of Medicine Aurora Colorado USA.ORCID https://orcid.org/0000-0002-2227-6265
Pediatric Pulmonary Hypertension Network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of antithrombotic therapy in pulmonary hypertension (PH) remains uncertain, with conflicting adult data and limited pediatric evidence. This study aimed to describe real-world antithrombotic use in pediatric PH utilizing Pediatric Pulmonary Hypertension Network (PPHNet) registry data and a survey of PPHNet centers. We analyzed data of 1,716 patients from the PPHNet registry (2014-2024), comparing characteristics of those who received aspirin or warfarin with those who did not. A survey on real-world antithrombotic use was also distributed to 12 North American PPHNet centers in 2023. Eighteen percent of subjects received aspirin and 7% received warfarin. Patients who received aspirin or warfarin were more likely to have idiopathic/heritable PH. Aspirin or warfarin-treated patients demonstrated higher-risk features as evidenced by use of PH-targeted triple therapy (aspirin vs. no aspirin: 22% vs. 9%,

Indexed as

anticoagulationantiplateletpediatricpulmonary vascular disease

Identifiers

PMID42872129
PMCPMC13660712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.