ArticlePatient preference and adherence2026
Association of Physician-Patient Communication and Treatment Satisfaction with Adherence to Disease-Modifying Therapies Among Patients with Relapsing-Remitting Multiple Sclerosis: A Cross-Sectional Study.
Article in Patient preference and adherence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Adherence to disease modifying therapies (DMTs) is essential for treatment outcomes in relapsing-remitting multiple sclerosis (RRMS). Non-adherence has been associated with an increased risk of relapses, disease progression and higher healthcare costs; therefore, it is essential to identify factors associated with adherence. Purpose: The aim of the study was to evaluate self-reported adherence to therapeutic recommendation among patients with RRMS and to examine its associations with treatment satisfaction and physician-patient communication. Material and Methods: This cross-sectional online survey study included 165 patients with RRMS (67.27% women), with mean age 44.42 ± 10.43 years, treated at the Department of Neurology, Wroclaw Medical University. Adherence was assessed using the Adherence in Chronic Diseases Scale (ACDS), physician-patient communication with the 14-item Polish version of the Communication Assessment Tool (CAT), and treatment satisfaction with the SATMED-Q questionnaire. Associations with the ACDS score were examined by univariable linear regression and by a multivariable model specified a priori on conceptual and clinical grounds (CAT, SATMED-Q, age, sex, EDSS, comorbidities, place of residence, route of administration and disease duration), supported by regression diagnostics and by ordinal and robust-regression sensitivity analyses. Results: The mean ACDS score was 25.49 ± 2.51 (range 14-28). Applying the established cut-offs, 8 participants (4.8%) were classified as showing low, 80 (48.5%) intermediate and 77 (46.7%) high adherence. Patients reported high satisfaction with physician communication (mean CAT score: 61.61 ± 9.73) and with treatment (mean total SATMED-Q score 78.67 ± 15.91). In the a-priori multivariable model (n = 165; Conclusion: In this single-centre cross-sectional sample of patients with RRMS, higher self-reported treatment satisfaction and more favourable ratings of physician-patient communication were associated with modestly higher self-reported adherence scores, while greater disability was associated with lower adherence. Longitudinal and intervention studies are required to establish directionality and to determine whether communication-focused or shared decision-making interventions can improve adherence to disease-modifying therapies.
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