Evidence map›Paper›PMID 42872028›Full record

ArticleACS pharmacology & translational science2026

From Daffodils to Drug Leads: Amaryllidaceae Alkaloids Target Protein Translation in Chronic Lymphocytic Leukemia to Induce Selective Apoptosis.

Rong Chen, Ryan Rutledge, Carson W King, Yuling Chen, Ping Xiong, William G Wierda, Puppala Sathish, Antonio Evidente, Travis Anderson, William Plunkett and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rong ChenDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
Ryan RutledgeDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, Texas 78666, United States.
Carson W KingDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, Texas 78666, United States.
Yuling ChenDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
Ping XiongDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
William G WierdaDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
Puppala SathishDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, Texas 78666, United States.
Antonio EvidenteInstitute of Biomolecular Chemistry, National Research Council, 80078 Pozzuoli, Italy.ORCID https://orcid.org/0000-0001-9110-1656
Travis AndersonDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, Texas 78666, United States.
William PlunkettDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, United States.
Alexander KornienkoDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, Texas 78666, United States.ORCID https://orcid.org/0000-0003-2041-7367

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeting protein translation is a promising strategy in oncology, especially for malignancies dependent on short-lived survival factors. The clinical translation inhibitor homoharringtonine (HHT) was recently discontinued in the U.S. due to poor solubility and cardiotoxicity, creating an urgent need for new leads. We investigated structurally distinct Amaryllidaceae alkaloids, narciclasine (NCS), lycorine (LYC), and haemanthamine (HAEM), in models of chronic lymphocytic leukemia (CLL) and Richter transformation (RT). Using an optimized 10 L Soxhlet extraction of 'Carlton' daffodil bulbs, an unprecedented NCS yield of 250 mg/kg was achieved, doubling previous laboratory records. NCS showed potent activity against primary CLL cells and the RT-derived HPRT1 line (IC

Indexed as

Amaryllidaceae alkaloidsChronic Lymphocytic LeukemiaHaemanthamineLycorineNarciclasineTranslation inhibitors

Identifiers

PMID42872028
PMCPMC13659852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.