Case report: Butylphthalide-associated severe thrombocytopenia, a rare adverse drug reaction.

Chenyi Gong, Xiaoling Feng, Yeqing Hu, Jian Wang, Yanan Zhang, Xiaoyan Sun, Bing Zhang, Ying Liu, Hengya Zhu

Abstract readCase Reports

In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chenyi Gong *Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University, Huzhou, Zhejiang, China.

Xiaoling Feng *The Fifth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Yeqing Hu *Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University, Huzhou, Zhejiang, China.

Jian WangHuzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University, Huzhou, Zhejiang, China.

Yanan ZhangHuzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University, Huzhou, Zhejiang, China.

Xiaoyan SunHuzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University, Huzhou, Zhejiang, China.

Bing ZhangHuzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University, Huzhou, Zhejiang, China.

Ying LiuHuzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University, Huzhou, Zhejiang, China.

Hengya ZhuHuzhou Central Hospital, The Affiliated Central Hospital of Huzhou Normal University, Huzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Butylphthalide (DL-NBP) is a widely used neuroprotective agent for acute ischemic stroke. Although generally well-tolerated, severe thrombocytopenia as a rare adverse reaction has not been fully recognized. Herein, we report a severe case of probable DL-NBP-associated thrombocytopenia to increase clinical awareness and inform clinical management. Case Presentation: A 69-year-old male with hypertension was admitted for acute brainstem infarction. His hospitalization was complicated by catastrophic thrombocytopenia (min 1.0 × 10 Conclusion: Severe thrombocytopenia showed a temporal association with DL-NBP treatment. After excluding alternative etiologies, probable DL-NBP-associated thrombocytopenia was considered in this case.

Indexed as

butylphthalidecase reportcerebral infarctiondrug side effectsthrombocytopenia

Identifiers

PMID42871979

DOI10.3389/fphar.2026.1903450

PMCPMC13659440

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.