ArticleJHLT open2026
Agonal time in donation after circulatory death lung donors and associations with early recipient pulmonary allograft function and long-term post-transplant outcomes.
Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Background: Uptake of donation after circulatory death (DCD) in lung transplantation is limited by concerns surrounding ischemic injury. This study aimed to assess the effects of prolonged donor agonal time during DCD procurement on recipient outcomes. Methods: One thousand three hundred five DCD lung recipients from January 2016 to June 2024 from the Scientific Registry of Transplant Recipients were analyzed. Donor agonal time was measured from the start of the agonal phase (SpO Results: Splines of agonal time against either composite outcome were statistically insignificant after multivariate correction. A trend towards impaired allograft oxygenation was observed with increased agonal time until an inflection point at 13.9 minutes. In the cohort analysis, long-agonal recipients displayed higher rates of PaO Conclusions: Prolonged DCD donor agonal time is not significantly associated with impaired post-transplant recovery following DCD lung transplantation. Although prolonged agonal time was associated with increased graft failure, the exact contribution of donor agonal time to this outcome remains unclear.
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