ArticleJournal of inflammation research2026
Impact of Perioperative Buyang Huanwu-Based Traditional Chinese Medicine Intervention on Postoperative Venous Thromboembolism, Coagulation Markers and Systemic Inflammation: A Propensity Score-Weighted Retrospective Cohort Study.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to (1) evaluate, in a propensity-score-weighted retrospective cohort, the effectiveness and safety of a standardised perioperative Buyang Huanwu-based traditional Chinese medicine (TCM) decoction combined with standard low-molecular-weight heparin (LMWH) prophylaxis on the 30-day incidence of symptomatic and asymptomatic venous thromboembolism (VTE), (2) characterise the longitudinal trajectories of coagulation (D-dimer, fibrinogen) and inflammatory (C-reactive protein [CRP]) biomarkers and (3) quantify the net clinical benefit of this integrative approach. Methods: We conducted a retrospective cohort study of 1847 adult patients undergoing major general-surgical or gynaecological procedures between January 2020 and December 2024 at a tertiary integrative-medicine centre. Patients receiving a standardised perioperative TCM decoction based on the modified Buyang Huanwu Tang in addition to standard LMWH prophylaxis ( Results: After IPTW adjustment, TCM intervention was associated with significantly reduced 30-day VTE incidence (hazard ratio [HR]: 0.58, 95% confidence interval [CI]: 0.41-0.82, Conclusion: Perioperative Buyang Huanwu-based TCM combined with standard LMWH prophylaxis significantly reduces postoperative VTE risk - for both symptomatic and ultrasound-detected asymptomatic events - through accelerated resolution of coagulation and inflammatory cascades, without increasing bleeding or 90-day all-cause mortality. These findings support the integration of standardised TCM into enhanced-recovery-after-surgery protocols, particularly for moderate- to high-risk surgical patients in whom anticoagulation intensification may be contraindicated.
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