ArticleEuropean urology open science2026
Global Direct In-scope Suction Study: An EAU-endourology Multicenter Prospective Collaboration (DISS-study).
Article in European urology open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05297331 (A Prospective Assessment of the Perioperative Parameter and Treatment Outcomes of Urinary Calculi - International Registry), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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A Prospective Assessment of the Perioperative Parameter and Treatment Outcomes of Urinary Calculi - International Registry
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Authors and funding
26 authors.
Funding
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Abstract
Background: Direct in-scope suction (DISS) facilitates continuous stone dust evacuation during flexible ureteroscopy (FURS), but prospective evidence validating its clinical efficacy and safety remains limited. Objective: To evaluate the stone-free rates (SFRs), perioperative outcomes, and limitations of DISS during successfully completed FURS for renal and ureteric stones in real-world practice, with the primary outcome being 30-d computed tomography (CT)-determined SFR. Design setting and participants: A prospective, multicenter, investigator-led registry was conducted across 16 centers in 14 countries (NCT05297331). Adults undergoing FURS with the Pusen 7.5-Fr DISS scope for any-sized renal/ureteric stones were included. Outcome measurements and statistical analysis: The primary outcome was 30-d postoperative noncontrast CT SFR, classified as grade A (zero residual fragments [ZRF]) and grade B (single ≤2-mm fragment). Multivariable logistic regression identified predictors of ZRF status. Results and limitations: A total of 540 patients (median age 55 yr; 57% male) were enrolled. Anomalous kidneys were present in 12% (horseshoe 5.0% and malrotation 3.9%). Median stone volume was 590 mm Conclusions: Flexible ureteroscopy for kidney and ureteral stones using the 7.5-Fr DISS achieves high SFR with low morbidity in real-world practice. Stone burden remains a key determinant of complete renal stone clearance using DISS.
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