ArticleChemical science2026
Function-preserving photooxidation of AS1411 aptamer by a G-quadruplex-guided photosensitizer.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
AS1411 is a G-quadruplex (G4) aptamer that binds nucleolin (NCL) and is widely used to promote cancer-associated delivery of photoactive cargos. Yet the fate of AS1411 after photosensitizer loading and light activation remains unclear as reactive oxygen species (ROS) generation could disrupt its guanine-rich fold and abolish NCL recognition, or remain locally confined while preserving targeting function. Here, we address this question using DBI-POE, a heavy-atom-free dibenzothioxanthene imide photosensitizer combining G4 recognition, fluorescence activation, and ROS generation. In this system, AS1411 converts weakly emissive, radical-prone DBI-POE aggregates into a fluorescent G4-bound complex with singlet oxygen (
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Registered trials
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