Significant Associations of Achilles Tendon Thickness With Atherosclerotic Diseases and Atherosclerotic Risk Factors in Non-Familial Hypercholesterolemia Patients: A Cross-Sectional Study.

Mariko Hakoshima, Hidekatsu Yanai, Tatsuki Onomura, Hirohumi Sugimoto, Hisayuki Katsuyama

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Article in Journal of clinical medicine research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Mariko HakoshimaDepartment of Diabetes, Endocrinology and Metabolism, National Kohnodai Medical Center, Japan Institute for Health Security, Chiba, Japan.

Hidekatsu YanaiDepartment of Diabetes, Endocrinology and Metabolism, National Kohnodai Medical Center, Japan Institute for Health Security, Chiba, Japan.

Tatsuki OnomuraDepartment of General Medicine, National Kohnodai Medical Center, Japan Institute for Health Security, Chiba, Japan.

Hirohumi SugimotoDepartment of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.

Hisayuki KatsuyamaDepartment of Diabetes, Endocrinology and Metabolism, National Kohnodai Medical Center, Japan Institute for Health Security, Chiba, Japan.

Funding

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6 · The paper itself

Abstract

Background: Achilles tendon thickness (ATT) is an important diagnostic tool for familial hypercholesterolemia (FH), a highly atherogenic genetic disorder. Although the available evidence remains limited, recent studies have reported associations between ATT and atherosclerotic diseases and their risk factors among non-FH patients. We investigated the relationships among ATT, carotid intima-media thickness (IMT), a marker of systemic atherosclerosis, and atherosclerotic risk factors, including diabetes, dyslipidemia, and atherosclerotic diseases, in non-FH patients. Methods: This cross-sectional survey was conducted at the National Kohnodai Medical Center, Japan. Patients who underwent ultrasonographic measurements of both ATT and carotid IMT were included. Clinical data were obtained using medical records and included demographic characteristics, anthropometric measurements, blood pressure, comorbidities, and biochemical parameters. Results: A total of 1,000 patients (512 males, 488 females) were enrolled. The mean age was 65 ± 14 years, the mean body mass index (BMI) was 24.6 ± 4.9 kg/m Conclusion: ATT levels were significantly associated with BMI and dyslipidemia, and were significantly higher in non-FH patients with CAD, carotid artery stenosis, and diabetes than in non-FH patients without such diseases.

Indexed as

Achilles tendon thicknessAtherosclerotic risk factorsCardiovascular diseaseDiabetesHigh-density lipoprotein

Identifiers

PMID42871747

DOI10.14740/jocmr6614

PMCPMC13661098

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