Evidence map›Paper›PMID 42871632›Full record

ArticleResuscitation plus2026

Intra-arrest strategies to treat cardiac arrest due to a non-opioid toxicological causes in adults and children: a systematic review.

Keith Couper, Amani Alenazi, James Gray, Brian Grunau, Stephan Katzenschlager, Ben Rutherford, Michael D Simpson, Ian R Drennan, Barney Scholefield, Eric J Lavonas and 1 more

Abstract read
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In one paragraph

Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Keith CouperWarwick Medical School, University of Warwick, Coventry, UK.
Amani AlenaziWarwick Medical School, University of Warwick, Coventry, UK.
James GrayDivision of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Brian GrunauCentre for Advancing Health Outcomes, St. Paul's Hospital, Vancouver, British Columbia, Canada.
Stephan KatzenschlagerHeidelberg University, Medical Faculty Heidelberg, Department of Anaesthesiology, Heidelberg, Germany.
Ben RutherfordWarwick Medical School, University of Warwick, Coventry, UK.
Michael D SimpsonDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Ian R DrennanInterdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, Toronto, Canada.
Barney ScholefieldDepartment of Critical Care Medicine, The Hospital for Sick Children, Toronto, Canada.
Eric J LavonasRocky Mountain Poison and Drug Safety, Denver Health, Denver, CO, USA.
Advanced Life Support and Pediatric Life Support Task Forces of the International Liaison Committee on Resuscitation

Funding

Training Program in Resuscitation ScienceT32HL155020 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Michael William Donnino, Robert Yeh · 2021 to 2026
$2.6M
NHLBI NIH HHS T32 HL155020
6 · The paper itself

Abstract

Objective: To summarise evidence on the effectiveness of specific alterations to standard advanced life support during ongoing cardiopulmonary resuscitation in adults and children with cardiac arrest due to a presumed toxicological cause. Methods: We searched MEDLINE (OVID platform), Embase (OVID platform), and Cochrane CENTRAL from inception to 22nd July 2026 for relevant observational and interventional studies with a control group. We excluded studies focussed specifically on opioid toxicity. Two authors independently screened studies for inclusion. Our primary outcome was 30-day survival. We assessed risk of bias using the Cochrane recommended tools and certainty of evidence using the GRADE system. Results: We identified four observational studies, of which none specifically focused on children and three included fewer than 100 patients. Studies examined general toxicological causes ( Conclusion: Current evidence does not support the modification of standard advanced life support during cardiac arrest due to a presumed toxicological cause in adults or children.

Indexed as

Cardiac arrestCardiopulmonary resuscitationPoisonsSystematic reviewToxicology

Identifiers

PMID42871632
PMCPMC13659757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.