Evidence map›Paper›PMID 42871611›Full record

ArticleACS pharmacology & translational science2026

Cardioprotection Is a Delivery Problem: A First-Medical-Contact Framework for Acute Myocardial Infarction.

Vibhudutta Awasthi, Tarun W Dasari, Kenichi A Tanaka

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vibhudutta AwasthiDepartment of Pharmaceutical Sciences, University of Oklahoma College of Pharmacy, 1110 North Stonewall Avenue, Oklahoma City, Oklahoma 73117, United States.ORCID https://orcid.org/0000-0002-3611-9009
Tarun W DasariDepartment of Internal Medicine, Cardiovascular Diseases Section, University of Oklahoma College of Medicine, 800 Stanton L. Young Blvd., Oklahoma City, Oklahoma 73104, United States.
Kenichi A TanakaDepartment of Anesthesiology, University of Oklahoma Health Campus, 920 Stanton L. Young Blvd., Oklahoma City, Oklahoma 73104, United States.

Funding

Mechanism of F-18-fluorodeoxyglucarate accrual in myocardial injuryR01HL169530 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI VIBHUDUTTA AWASTHI · 2024 to 2026
$1.1M
NHLBI NIH HHS R01 HL169530
6 · The paper itself

Abstract

Dozens of agents that limit reperfusion injury preclinically have failed clinically. These failures are architectural, not biological: the right biology reaches the wrong place, as the wrong molecule, at the wrong time, judged by the wrong end point. We recast each as a design constraint and specify a staged regimen anchored at first medical contact.

Indexed as

cardioprotectionfirst medical contactischemia−reperfusion injurymitochondrial permeability transitionnanoparticle drug deliverySTEMI

Identifiers

PMID42871611
PMCPMC13659830

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.