ArticleCureus2026
Association Between Left Atrial Volume Index (LAVI) and Glycemic Control (HbA1c) in Patients With Atrial Fibrillation and Type 2 Diabetes Mellitus.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
backgroundGlycemic control and left atrial remodeling in patients with concomitant type 2 diabetes mellitus (T2DM) and atrial fibrillation (AF) remain unclear. In this study, we examined the association between glycated hemoglobin (HbA1c) and left atrial volume index (LAVI) in this high-risk population.
methodsA total of 700 patients with AF and T2DM were included in this retrospective study. We used medical records to obtain HbA1c and echocardiographic parameters. We assessed LAVI as a continuous variable and as a binary variable (enlarged LAVI > 34 mL/m²). We used Spearman correlation, multivariable linear regression, and binary logistic regression to examine the relationship between HbA1c and LAVI.
resultsThere was a significant association between higher HbA1c and greater LAVI (Spearman's ρ = 0.287, p < 0.001). After multivariable adjustment, each 1% increase in HbA1c was associated with a 1.678 mL/m² increase in LAVI. Higher HbA1c was independently associated with increased odds of enlarged LAVI (adjusted odds ratio (OR) = 1.701, 95% confidence interval (CI): 1.391-2.081, p < 0.001). Hypertension, heart failure, and chronic kidney disease were also independently associated with enlarged LAVI.
conclusionIn patients with concurrent AF and T2DM, higher HbA1c was independently associated with larger LAVI and higher odds of left atrial enlargement (LAE). Future prospective studies are warranted to determine whether improved glycemic control can influence atrial remodeling.
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