ArticleInternational journal of hypertension2026
From Adiposity to Diastolic Dysfunction: The Integrated Role of Epicardial Fat, Autonomic Dysregulation, and Morning Blood Pressure Surge in Obesity.
Article in International journal of hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objective: Although the association between obesity and left ventricular diastolic dysfunction (LVDD) is well established, the concurrent associations of epicardial adipose tissue (EAT), sleep-trough (prewaking) morning blood pressure surge (MBPS), and autonomic imbalance with LVDD have not been fully elucidated. This study aimed to evaluate the associations of EAT thickness, MBPS, and heart rate variability (HRV) parameters with LVDD in obese adults and to assess the cross-sectional discriminatory performance of these multimodal markers. Methods: This cross-sectional study included 240 individuals, comprising 120 obese participants (body mass index ≥ 30 kg/m Results: Compared with controls, obese participants exhibited greater EAT thickness (6.5 ± 1.7 vs. 4.0 ± 1.2 mm), higher MBPS (33 ± 10 vs. 21 ± 7 mmHg), increased LF/HF ratio, and lower SDNN and RMSSD values (all Conclusion: In obese adults, increased epicardial adiposity, exaggerated MBPS, and autonomic dysfunction coexist with LVDD. Integrated assessment of structural (EAT), hemodynamic (MBPS), and autonomic (SDNN) markers may facilitate cross-sectional identification of LVDD and improve phenotypic characterization in obesity.
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