Evidence map›Paper›PMID 42871584›Full record

ArticleLaryngoscope investigative otolaryngology2026

Evaluating the Efficacy of Chitosan-l-DOPA MAP Gel for Acute Laryngeal Injury.

Areli Rodriguez-Ayala, Ryan Stepp, Naushin Ali, Vincent Gray, Rachel Letteri, Patrick S Cottler, Donald R Griffin, James J Daniero

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Areli Rodriguez-AyalaDepartment of Biomedical Engineering University of Virginia Charlottesville Virginia USA.ORCID https://orcid.org/0000-0002-0783-6893
Ryan SteppDepartment of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.ORCID https://orcid.org/0009-0003-2529-878X
Naushin AliDepartment of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.
Vincent GrayDepartment of Chemical Engineering University of Virginia Charlottesville Virginia USA.
Rachel LetteriDepartment of Chemical Engineering University of Virginia Charlottesville Virginia USA.
Patrick S CottlerDepartment of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.ORCID https://orcid.org/0000-0002-2542-6142
Donald R GriffinDepartment of Biomedical Engineering University of Virginia Charlottesville Virginia USA.ORCID https://orcid.org/0000-0002-3458-867X
James J DanieroDepartment of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.ORCID https://orcid.org/0000-0003-3693-4617

Funding

Engineered Biomaterial for Endoscopic Treatment of Airway FibrosisR21AR077163 · NIAMS · UNIVERSITY OF VIRGINIA · PI DANIERO, JAMES J., GRIFFIN, DONALD RICHIERI · 2021 to 2022
$368k
NIAMS NIH HHS R21 AR077163
6 · The paper itself

Abstract

Objectives: This study aimed to evaluate the efficacy of an innovative chitosan-l-DOPA-modified microporous annealed particle (MAP) hydrogel in reducing fibrosis and enhancing healing in the treatment of Acute Laryngeal Injury (ALgI). Methods: Four experimental treatment groups: uninjured control, sham treated control (saline), nonbioactive MAP gel (sMAP), and Chitosan-l-DOPA MAP gel (dMAP2) were evaluated in a validated rabbit model of acute laryngeal injury, consisting of posterior glottis mucosal stripping and debridement followed by treatment at 14 days postinjury. At Days 4 and 14 posttreatment, histological evaluations were performed to evaluate the posterior glottic thickness (PGT), collagen content and type within the posterior glottis via immunofluorescence staining, glycosaminoglycan (GAG) content via Alcian blue staining, and collagen fiber orientation through picrosirius red staining. Results: At Day 4, the dMAP2 treatment performed similarly to the standard MAP gel, indicating a consistent inflammatory profile. Though at Day 14, the dMAP2 treated injuries demonstrated a significant increase in PGT compared to uninjured controls ( Conclusions: The dMAP2 gel improved healing with organized tissue remodeling compared to untreated controls through the proliferative phase of wound healing. Level of Evidence: 3.

Indexed as

acute laryngeal injurychitosanl‐DOPAmicroporous annealed particle hydrogel

Identifiers

PMID42871584
PMCPMC13659047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.