ArticleFrontiers in psychiatry2026
Patient-derived stem cell models of brain endothelial-neuron interactions in early course psychosis.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
Introduction: Early-course psychosis (ECP) exhibits marked heterogeneity in illness trajectories, with a substantial subset of individuals developing progressive symptomatic, cognitive, and functional decline. Although growing evidence implicates blood-brain barrier (BBB) and neurovascular unit (NVU) dysfunction in psychosis spectrum disorders, direct links between longitudinal clinical trajectories and disease-related cellular phenotypes remain insufficiently characterized. Methods and analysis: This protocol describes a standardized stem cell-based framework to model BBB and NVU dysfunction in ECP using induced pluripotent stem cells (iPSCs) derived from peripheral blood mononuclear cells (PBMCs) within a longitudinally characterized clinical cohort. The approach integrates donor-specific Ethics and dissemination: Ethical approval and informed consent for this study was obtained and the findings will be disseminated through publication in peer-reviewed journals and presentations at scientific conferences.
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